Western Blot (WB)
(PROX-1 Antibody (S197) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the PROX-1 antibody detected the PROX-1 protein (arrow).)
Rabbit PROX1 Polyclonal Antibody | anti-PROX1 antibody
PROX1 Antibody (S197)
Western Blot (WB)
(PROX-1 Antibody (S197) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the PROX-1 antibody detected the PROX-1 protein (arrow).)
Western Blot (WB)
(PROX-1 Antibody (S197) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the PROX-1 antibody detected the PROX-1 protein (arrow).)
Dyer, M.A., et al., Nat. Genet. 34(1):53-58 (2003).
Hong, Y.K., et al., Dev. Dyn. 225(3):351-357 (2002).
Petrova, T.V., et al., EMBO J. 21(17):4593-4599 (2002).
Mouta Carreira, C., et al., Cancer Res. 61(22):8079-8084 (2001).
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Description
PROX1: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons. Belongs to the Prospero homeobox family.
Protein type: DNA-binding; Transcription factor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1q41
Cellular Component: cytoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor binding; protein binding; DBD domain binding; DNA binding; LBD domain binding; transcription corepressor activity; transcription factor activity
Biological Process: lens development in camera-type eye; neural tube development; circadian rhythm; transcription from RNA polymerase II promoter; positive regulation of cyclin-dependent protein kinase activity; ventricular cardiac myofibril development; muscle thin filament assembly; atrial cardiac muscle morphogenesis; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cell fate determination; olfactory placode formation; negative regulation of cell proliferation; venous blood vessel morphogenesis; lymphangiogenesis; positive regulation of cell proliferation; pancreas development; ventricular cardiac muscle morphogenesis; kidney development; response to nutrient levels; dentate gyrus development; negative regulation of transcription factor activity; positive regulation of cell cycle; regulation of circadian rhythm; liver development; cerebellar granule cell differentiation; dorsal spinal cord development; negative regulation of viral genome replication; regulation of gene expression; otic placode formation; embryonic retina morphogenesis in camera-type eye; positive regulation of endothelial cell proliferation; optic placode formation involved in camera-type eye; positive regulation of transcription from RNA polymerase II promoter; brain development; negative regulation of transcription, DNA-dependent; retina morphogenesis in camera-type eye; lung development
Research Articles on PROX1
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Product Notes
The PROX1 prox1 (Catalog #AAA9209316) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 175-206. The PROX1 Antibody (S197) reacts with Human (Predicted Reactivity: Mouse) and may cross-react with other species as described in the data sheet. AAA Biotech's PROX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PROX1 prox1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PROX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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