Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Serum; Lane2: Human Jurkat Cells.)
Rabbit anti-Mouse Protein Tyrosine Phosphatase Receptor Type J Polyclonal Antibody | anti-PTPRJ antibody
Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- TGDG SNVTSNFTKD PSILIPELIP GVSYTVKILT QVGDGTTSLV PGWNLFCTEP EPVTSFHCEV VPKEPALVLK WACPFGMYTG FELGVRSDSW DNMTRLENCT SDDDTECRTE VAYLNFSTSY NISIATLSCG KMALPAQNIC TTGITDPPTP DGSPNITSVS HNSVKVKFSG FEASHGPIKA YAVILTTGEA AQPSADVLKY TYEDFKRGAS DTYVTYLIRI EEKGQSQGLS EVLNYEIDVG NQSTTLGYYN
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Serum; Lane2: Human Jurkat Cells.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Mouse Serum; Lane2: Human Jurkat Cells.)
Western Blot (WB)
(Western Blot: Sample: Recombinant PTPRJ, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant PTPRJ, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Liver Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Stomach Tissue)
NCBI and Uniprot Product Information
Uniprot Description
PTPRJ: Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 2 E1|2 50.19 cM
Cellular Component: cell junction; cell projection; cell surface; extracellular exosome; immunological synapse; integral component of membrane; intercellular junction; membrane; plasma membrane
Molecular Function: beta-catenin binding; delta-catenin binding; gamma-catenin binding; hydrolase activity; mitogen-activated protein kinase binding; phosphoprotein phosphatase activity; phosphoric monoester hydrolase activity; platelet-derived growth factor receptor binding; protein kinase binding; protein tyrosine phosphatase activity
Biological Process: blood coagulation; dephosphorylation; heart development; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of protein kinase B signaling cascade; negative regulation of receptor activity; negative regulation of T cell receptor signaling pathway; negative regulation of vascular permeability; oligodendrocyte differentiation; platelet-derived growth factor receptor signaling pathway; positive chemotaxis; positive regulation of cell adhesion; positive regulation of cell-matrix adhesion; positive regulation of focal adhesion assembly; positive regulation of macrophage chemotaxis; positive regulation of platelet activation; positive regulation of protein kinase B signaling; protein amino acid dephosphorylation; regulation of cell adhesion; vasculogenesis
Research Articles on PTPRJ
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Product Notes
The PTPRJ ptprj (Catalog #AAA2028171) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Protein Tyrosine Phosphatase Receptor Type J (PTPRJ) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Protein Tyrosine Phosphatase Receptor Type J can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-5ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the PTPRJ ptprj for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- TGDG SNVTSNFTKD PSILIPELIP GVSYTVKILT QVGDGTTSLV PGWNLFCTEP EPVTSFHCEV VPKEPALVLK WACPFGMYTG FELGVRSDSW DNMTRLENCT SDDDTECRTE VAYLNFSTSY NISIATLSCG KMALPAQNIC TTGITDPPTP DGSPNITSVS HNSVKVKFSG FEASHGPIKA YAVILTTGEA AQPSADVLKY TYEDFKRGAS DTYVTYLIRI EEKGQSQGLS EVLNYEIDVG NQSTTLGYYN. It is sometimes possible for the material contained within the vial of "Protein Tyrosine Phosphatase Receptor Type J, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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