Rabbit Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator Polyclonal Antibody | anti-PRKRA antibody
Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator (PRKRA, PACT, Retina and Anterior Neural Fold Homeobox Protein, RAX, Retinal Homeobox Protein, Retinal Homeobox Protein Rx, RX, RX Homeobox)
Gene Names
PRKRA; RAX; PACT; DYT16; HSD14; PRKRA
Reactivity
Canine, Human, Monkey
Applications
Western Blot
Purity
Affinity PurifiedPurified by peptide immunoaffinity chromatography.
Synonyms
Protein Kinase; Interferon-inducible Double Stranded RNA Dependent Activator; Polyclonal Antibody; Interferon-inducible Double Stranded RNA Dependent Activator (PRKRA; PACT; Retina and Anterior Neural Fold Homeobox Protein; RAX; Retinal Homeobox Protein; Retinal Homeobox Protein Rx; RX; RX Homeobox); Anti -Protein Kinase; anti-PRKRA antibody
Host
Rabbit
Reactivity
Canine, Human, Monkey
Clonality
Polyclonal
Isotype
IgG
Specificity
The amino acid sequence used as immunogen is 100% homologous in human, canine, monkey, 85% homologous in chicken and 78% homologous in zebrafish, mouse and rat. Species Crossreactivity: canine, Human, Monkey
Purity/Purification
Affinity Purified
Purified by peptide immunoaffinity chromatography.
Purified by peptide immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Applicable Applications for anti-PRKRA antibody
Western Blot (WB)
Application Notes
Suitable for use in Western Blot.
Positive Control
Jurkat cell lysate
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-PRKRA antibody
Principal Names: Retinal and anterior neural fold Homeobox (Rax); Retinal Homeobox protein Rx; Official Gene Symbol: RAX Gen Bank Accession Number: NP_038463 Gene ID: 30062 (Human) Gene Map Locus: 18q21.32 (Human) Rax, a novel transcription factor, is a human homolog of Drosophila Rx protein. It is a significant member of Rx protein family and consists of a highly-conserved N-terminal DNA-binding paired-like Homeodomain. It interacts with PCE-1 and is one of the earliest expressed proteins stimulating establishment and proliferation of retinal progenitor cells. Its expression is essential in determining the fate of normal eye development. Irregular expression of Rax has profound effects on eye morphogenesis. Mutations in Rax gene have been detected in clinical conditions like Anophthalmia and Sclerocornea.
Product Categories/Family for anti-PRKRA antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
34,404 Da
NCBI Official Full Name
protein kinase, interferon-inducible double stranded RNA dependent activator
NCBI Official Synonym Full Names
protein kinase, interferon-inducible double stranded RNA dependent activator
NCBI Official Symbol
PRKRA
NCBI Official Synonym Symbols
RAX; PACT; DYT16; HSD14; PRKRA
NCBI Protein Information
interferon-inducible double stranded RNA-dependent protein kinase activator A; OTTHUMP00000205652; PKR-associated protein X; PKR-associating protein X; protein activator of the interferon-induced protein kinase; protein kinase, interferon-inducible double stranded RNA-dependent activator
UniProt Protein Name
Interferon-inducible double stranded RNA-dependent protein kinase activator A
UniProt Gene Name
PRKRA
UniProt Synonym Gene Names
PACT; RAX
UniProt Entry Name
PRKRA_HUMAN
NCBI Description
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
Uniprot Description
PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.
Protein type: RNA processing; RNA-binding; Activator
Chromosomal Location of Human Ortholog: 2q31.2
Cellular Component: nucleoplasm; membrane; perinuclear region of cytoplasm; cytoplasm; cytosol
Molecular Function: protein binding; protein homodimerization activity; enzyme activator activity
Biological Process: positive regulation of catalytic activity; negative regulation of cell proliferation; skeletal morphogenesis; response to virus; outer ear morphogenesis; gene expression; immune response; middle ear morphogenesis; protein amino acid phosphorylation; RNA interference, production of siRNA
Disease: Dystonia 16
Research Articles on PRKRA
1. Observational study of gene-disease association. (HuGE Navigator)
2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
3. writer's cramp as presenting symptom is not associated with mutations in DYT11, DYT16, but it can be the sole manifestation of DYT1 GAG deletion mutation carriers.
4. Strong protein kinase R (PKR) binding is needed for PACT-mediated PKR activation and phosphorylation in vivo.
5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
6. DYT16, a novel young-onset dystonia-parkinsonism disorder, identification of a segregating mutation in the stress-response protein PRKRA.
7. TRBP controls PACT activation of PKR, an activity that is reversed by stress.
8. A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient.
9. Results indicate that human TRBP and PACT directly interact with each other and associate with Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA.
10. Us11 protein of herpes simplex virus type 1 can block PKR activation by PACT both in vitro and in vivo
2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
3. writer's cramp as presenting symptom is not associated with mutations in DYT11, DYT16, but it can be the sole manifestation of DYT1 GAG deletion mutation carriers.
4. Strong protein kinase R (PKR) binding is needed for PACT-mediated PKR activation and phosphorylation in vivo.
5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
6. DYT16, a novel young-onset dystonia-parkinsonism disorder, identification of a segregating mutation in the stress-response protein PRKRA.
7. TRBP controls PACT activation of PKR, an activity that is reversed by stress.
8. A heterozygous frameshift mutation in PRKRA (DYT16) associated with generalised dystonia in a German patient.
9. Results indicate that human TRBP and PACT directly interact with each other and associate with Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA.
10. Us11 protein of herpes simplex virus type 1 can block PKR activation by PACT both in vitro and in vivo
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Product Notes
The PRKRA prkra (Catalog #AAA618979) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator (PRKRA, PACT, Retina and Anterior Neural Fold Homeobox Protein, RAX, Retinal Homeobox Protein, Retinal Homeobox Protein Rx, RX, RX Homeobox) reacts with Canine, Human, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the PRKRA prkra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Protein Kinase, Interferon-inducible Double Stranded RNA Dependent Activator, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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