Rabbit anti-Human Prostate Apoptosis Response Protein 4 Polyclonal Antibody | anti-PAWR antibody

Prostate Apoptosis Response Protein 4 (Par4 Induced by Effectors of Apoptosis, PAWR, PRKC Apoptosis WT1 Regulator Protein, Prostate Apoptosis Response 4 Protein, Prostate Apoptosis Response Protein PAR-4, Transcriptional Repressor PAR4, WT1 Interacting Pr

Cat. Num. AAA616948

• Gene Names: PAWR; PAR4; Par-4
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Prostate Apoptosis Response Protein 4; Polyclonal Antibody; Prostate Apoptosis Response Protein 4 (Par4 Induced by Effectors of Apoptosis; PAWR; PRKC Apoptosis WT1 Regulator Protein; Prostate Apoptosis Response 4 Protein; Prostate Apoptosis Response Protein PAR-4; Transcriptional Repressor PAR4; WT1 Interacting Pr; Anti -Prostate Apoptosis Response Protein 4 (Par4 Induced by Effectors of Apoptosis; anti-PAWR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Species Crossreactivity: Human. Other species have not been tested.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.

• Applicable Applications for anti-PAWR antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Cellular Localization: Cytoplasm. Nucleus. Note: Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-PAWR antibody

The tumor suppressor WT1 represses and activates transcription. The loss and/or imbalance of the dual transcriptional activity of WT1 may contribute to Wilms' tumor. Par-4 (for prostate apoptosis response) is a WT1-interacting protein that also functions as a transcriptional repressor. Par-4 contains a putative leucine zipper domain and is specifically upregulated during apoptosis of prostate cells.

Product Categories/Family for anti-PAWR antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 55769533
• NCBI GeneID: 5074
• NCBI Accession #: NP_002574.2
• NCBI GenBank Nucleotide #: NM_002583.2
• UniProt Accession #: Q96IZ0; O75796; Q6FHY9; Q8N700
• Molecular Weight: 36,568 Da
• NCBI Official Full Name: PRKC apoptosis WT1 regulator protein
• NCBI Official Synonym Full Names: PRKC, apoptosis, WT1, regulator
• NCBI Official Symbol: PAWR
• NCBI Official Synonym Symbols: PAR4; Par-4
• NCBI Protein Information: PRKC apoptosis WT1 regulator protein; WT1-interacting protein; prostate apoptosis response-4; transcriptional repressor PAR4; prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4
• UniProt Protein Name: PRKC apoptosis WT1 regulator protein
• Protein Family: PRKC apoptosis WT1 regulator protein
• UniProt Gene Name: PAWR
• UniProt Synonym Gene Names: PAR4; Par-4
• UniProt Entry Name: PAWR_HUMAN

NCBI Description

The tumor suppressor WT1 represses and activates transcription. The protein encoded by this gene is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. This protein is specifically upregulated during apoptosis of prostate cells. [provided by RefSeq, Jul 2008]

Uniprot Description

PAR-4: a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 12q21

Cellular Component: cytoplasm; plasma membrane; actin filament; nucleus; actin cytoskeleton

Molecular Function: leucine zipper domain binding; protein binding; enzyme binding; actin binding; transcription corepressor activity

Biological Process: actin filament bundle formation; negative regulation of cell proliferation; interleukin-2 biosynthetic process; negative regulation of T cell proliferation; transcription, DNA-dependent; apoptosis; positive regulation of apoptosis; negative regulation of T cell receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; negative regulation of B cell proliferation; positive regulation of amyloid precursor protein biosynthetic process