Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: PDCD6 knockout Hela cell lysate; Predicted MW: 22,7kd Observed MW: 23kd Primary Ab: 1ug/ml Rabbit Anti-Human PDCD6 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Rabbit anti-Human Programmed Cell Death Protein 6 (PDCD6) Polyclonal Antibody | anti-PDCD6 antibody
Biotin-Linked Polyclonal Antibody to Programmed Cell Death Protein 6 (PDCD6)
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: PDCD6 knockout Hela cell lysate; Predicted MW: 22,7kd Observed MW: 23kd Primary Ab: 1ug/ml Rabbit Anti-Human PDCD6 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
Knockout Validation
(Knockout Validation: Lane 1: Wild-type Hela cell lysate; Lane 2: PDCD6 knockout Hela cell lysate; Predicted MW: 22,7kd Observed MW: 23kd Primary Ab: 1ug/ml Rabbit Anti-Human PDCD6 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody (#MBS2086047))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]
Uniprot Description
PDCD6: Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway. Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity.
Chromosomal Location of Human Ortholog: 5p15.33
Cellular Component: COPII vesicle coat; cytoplasm; cytoplasmic vesicle; endoplasmic reticulum; endoplasmic reticulum membrane; endosome; Golgi membrane; nucleus
Molecular Function: calcium ion binding; calcium-dependent cysteine-type endopeptidase activity; calcium-dependent protein binding; identical protein binding; magnesium ion binding; molecular adaptor activity; protein anchor; protein binding; protein dimerization activity; protein homodimerization activity
Biological Process: activation of cysteine-type endopeptidase activity involved in apoptotic process; angiogenesis; COPII vesicle coating; ER to Golgi vesicle-mediated transport; intracellular protein transport; negative regulation of protein kinase B signaling cascade; negative regulation of TOR signaling; negative regulation of vascular endothelial growth factor receptor signaling pathway; neural crest cell development; neural crest formation; positive regulation of angiogenesis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of endothelial cell proliferation; proteolysis; response to calcium ion
Research Articles on PDCD6
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Product Notes
The PDCD6 pdcd6 (Catalog #AAA2096792) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Programmed Cell Death Protein 6 (PDCD6) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Programmed Cell Death Protein 6 (PDCD6) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the PDCD6 pdcd6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Programmed Cell Death Protein 6 (PDCD6), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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