Rabbit anti-Human, Mouse PRND Polyclonal Antibody | anti-PRND antibody

PRND Antibody

Cat. Num. AAA9630853

• Gene Names: PRND; DPL; PrPLP; DOPPEL; dJ1068H6.4
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PRND; Polyclonal Antibody; PRND Antibody; dJ1068H6.4; DPL; Dublet; MGC41841; Prion gene complex downstream; Prion like protein doppel; Prion protein 2 (dublet); Prion protein 2; Prion-like protein doppel; PRND_HUMAN; PrPLP; anti-PRND antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PRND Antibody detects endogenous levels of PRND.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PRND antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human PRND.
• Conjugation: Unconjugated
• Similarity: A short helical region is required and sufficient for Cu(2+) binding. Belongs to the prion family.
• Post Translational Modifications: N-glycosylated. N-glycosylated at two distinct sites.O-glycosylated.
• Tissue Specificity: Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).
• Function: Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu(2+).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-PRND antibody

Cell membrane; Lipid-anchor; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 34335268
• NCBI GeneID: 23627
• NCBI Accession #: NP_036541.2
• NCBI GenBank Nucleotide #: NM_012409.3
• UniProt Accession #: Q9UKY0; Q9H311; Q9H312; Q9NTM4; A7U7M5
• Molecular Weight: 20,293 Da
• NCBI Official Full Name: prion-like protein doppel preproprotein
• NCBI Official Synonym Full Names: prion protein 2 (dublet)
• NCBI Official Symbol: PRND
• NCBI Official Synonym Symbols: DPL; PrPLP; DOPPEL; dJ1068H6.4
• NCBI Protein Information: prion-like protein doppel; prion gene complex, downstream
• UniProt Protein Name: Prion-like protein doppel
• Protein Family: Prion-like protein doppel
• UniProt Gene Name: PRND
• UniProt Synonym Gene Names: DPL
• UniProt Entry Name: PRND_HUMAN

NCBI Description

This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]

Uniprot Description

PRND: This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders. [provided by RefSeq, Jul 2008]

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: plasma membrane

Biological Process: protein homooligomerization