Rabbit PRMT2 Polyclonal Antibody | anti-PRMT2 antibody

PRMT2 Polyclonal Antibody

Cat. Num. AAA3011363

• Gene Names: PRMT2; HRMT1L1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PRMT2; Polyclonal Antibody; PRMT2 Polyclonal Antibody; ANM2_HUMAN; EC 2.1.1.; histone arginine N methyltransferase PRMT2; Histone-arginine N-methyltransferase PRMT2; HMT 1; HMT1 (hnRNP methyltransferase S. cerevisiae) like 1; HMT1; HMT1 hnRNP methyltransferase like 1; hnRNP methyltransferase (S. cerevisiae) like 1; hnRNP methyltransferase like 1; Hrmt1l1; MGC111373; PRMT 2; PRMT2 alpha; prmt2; PRMT2 beta; PRMT2 gamma; PRMT2 protein; PRMT2L2; Protein arginine methyltransferase 2; Protein arginine N methyltransferase 2; Protein arginine N-methyltransferase 2; Zf2; anti-PRMT2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PRMT2 polyclonal antibody detects endogenous levels of PRMT2 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 433

• Applicable Applications for anti-PRMT2 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200
• Immunogen: Recombinant full length Human PRMT2.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot analysis of extracts of mouse lung, using PRMT2 antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver injury using PRMT2 antibody at dilution of 1:100 (x40 lens).)

Related Product Information for anti-PRMT2 antibody

PRMT2 (Protein arginine N-methyltransferase 2) is a 433 amino acid protein encoded by the human gene PRMT2. PRMT2 belongs to the protein arginine N-methyltransferase family and contains one SH3 domain. The primary function of protein methyltransferases is the post-translational methylation of arginine residues. The PRMT family of proteins contains related putative methyltransferase domains that modify chromatin and regulate cellular transcription. Some family members, PRMT1 and PRMT4, show transcriptional modulation and intracellular signaling. Through a highly conserved S-adenosylmethionine-binding domain, PRMT2 inhibits NF-kappaB-dependent transcription and promotes apoptosis. PRMT2 has this effect by blocking nuclear export of IkappaB-alpha through a leptomycin-sensitive pathway, which increases nuclear IkappaB-alpha and decreases NF-kappaB DNA binding. PRMT2 also renders cells susceptible to apoptosis by cytokines or cytotoxic drugs.

NCBI and Uniprot Product Information

• NCBI GI #: 46255047
• NCBI GeneID: 3275
• NCBI Accession #: NP_001526
• NCBI GenBank Nucleotide #: NP_001526.2
• UniProt Accession #: P55345
• Molecular Weight: ~ 49kDa
• NCBI Official Full Name: protein arginine N-methyltransferase 2 isoform 1
• NCBI Official Synonym Full Names: protein arginine methyltransferase 2
• NCBI Official Symbol: PRMT2
• NCBI Official Synonym Symbols: HRMT1L1
• NCBI Protein Information: protein arginine N-methyltransferase 2
• UniProt Protein Name: Protein arginine N-methyltransferase 2
• UniProt Gene Name: PRMT2
• UniProt Synonym Gene Names: HMT1; HRMT1L1
• UniProt Entry Name: ANM2_HUMAN