Western Blot (WB)
(Anti-PRLR Picoband antibody, MBS177903, Western blottingAll lanes: Anti PRLR (MBS177903) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: SGC Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugPredicted bind size: 90KDObserved bind size: 90KD )
anti-Human PRLR Polyclonal Antibody | anti-PRLR antibody
Anti-PRLR Antibody
Western Blot (WB)
(Anti-PRLR Picoband antibody, MBS177903, Western blottingAll lanes: Anti PRLR (MBS177903) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: SGC Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugPredicted bind size: 90KDObserved bind size: 90KD )
Western Blot (WB)
(Anti-PRLR Picoband antibody, MBS177903, Western blottingAll lanes: Anti PRLR (MBS177903) at 0.5ug/mlLane 1: HELA Whole Cell Lysate at 40ugLane 2: SGC Whole Cell Lysate at 40ugLane 3: SW620 Whole Cell Lysate at 40ugPredicted bind size: 90KDObserved bind size: 90KD )
Background: PRLR (Prolactin Receptor) is a cytokine receptor. By somatic cell hybrid analysis and by in situ hybridization, Arden et al. (1989, 1990) demonstrated that the prolactin receptor gene resides in the same chromosomal region as the growth hormone receptor gene, which has been mapped to 5p13-p12. Cunningham et al. (1990) demonstrated that zinc greatly increases the affinity of GH for the extracellular binding domain of PRLR, although it is not required for binding of GH to the growth hormone receptor or for binding of prolactin to the prolactin receptor. By mutational analysis, they showed that a cluster of 3 residues (histidine-18, histidine-21, and glutamic acid-174) in GH and histidine-188 in PRLR (conserved in all PRL receptors but not GH receptors) are likely zinc-ion ligands.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer. [provided by RefSeq, Feb 2011]
Uniprot Description
PRLR: receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified.
Protein type: Receptor, cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5p13.2
Cellular Component: cell surface; extracellular region; integral to membrane; plasma membrane
Molecular Function: metal ion binding; ornithine decarboxylase activator activity; peptide hormone binding; prolactin receptor activity; protein binding; protein homodimerization activity
Biological Process: cell surface receptor linked signal transduction; embryo implantation; lactation; negative regulation of apoptosis; regulation of cell adhesion; regulation of epithelial cell differentiation; steroid biosynthetic process; T cell activation; transmembrane receptor protein tyrosine kinase activation (dimerization); tyrosine phosphorylation of JAK2 protein
Disease: Hyperprolactinemia; Multiple Fibroadenomas Of The Breast
Research Articles on PRLR
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Product Notes
The PRLR prlr (Catalog #AAA177903) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-PRLR Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PRLR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the PRLR prlr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRLR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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