Western Blot (WB)
(PRKRIR Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PRKRIR antibody detected the PRKRIR protein (arrow).)
Rabbit anti-Human PRKRIR Polyclonal Antibody | anti-PRKRIR antibody
PRKRIR Antibody (N-term)
Gene Names
PRKRIR; DAP4; THAP0; THAP12; P52rIPK
Reactivity
Human
Applications
Western Blot, ELISA
Purity
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
PRKRIR; Polyclonal Antibody; PRKRIR Antibody (N-term); 52 kDa repressor of the inhibitor of the protein kinase; p52rIPK; 58 kDa interferon-induced protein kinase-interacting protein; p58IPK-interacting protein; Death-associated protein 4; THAP domain-containing protein 0; DAP4; P52RIPK; THAP0; anti-PRKRIR antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit Ig
Specificity
This PRKRIR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the N-terminal region of human PRKRIR.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.5 (varies by lot)
Sequence Positions
102-130
Sequence Length
492
Applicable Applications for anti-PRKRIR antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~1:1000
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Western Blot (WB)
(PRKRIR Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PRKRIR antibody detected the PRKRIR protein (arrow).)
Western Blot (WB)
(PRKRIR Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the PRKRIR antibody detected the PRKRIR protein (arrow).)
Related Product Information for anti-PRKRIR antibody
Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth.
Product Categories/Family for anti-PRKRIR antibody
References
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Lee, J.H., et al. Korean J Gastroenterol 42(6):484-495(2003)
Lin, Y., et al. J. Biol. Chem. 277(50):47991-48001(2002)
Saelens, X., et al. J. Biol. Chem. 276(45):41620-41628(2001)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Lee, J.H., et al. Korean J Gastroenterol 42(6):484-495(2003)
Lin, Y., et al. J. Biol. Chem. 277(50):47991-48001(2002)
Saelens, X., et al. J. Biol. Chem. 276(45):41620-41628(2001)
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
87704
NCBI Official Full Name
52 kDa repressor of the inhibitor of the protein kinase
NCBI Official Synonym Full Names
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
NCBI Official Symbol
PRKRIR
NCBI Official Synonym Symbols
DAP4; THAP0; THAP12; P52rIPK
NCBI Protein Information
52 kDa repressor of the inhibitor of the protein kinase
UniProt Protein Name
52 kDa repressor of the inhibitor of the protein kinase
UniProt Gene Name
PRKRIR
UniProt Synonym Gene Names
DAP4; P52RIPK; THAP0; p52rIPK; p58IPK-interacting protein
UniProt Entry Name
P52K_HUMAN
Uniprot Description
PRKRIR: Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR- inhibitory function of P58IPK, resulting in restoration of kinase activity and suppression of cell growth. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protein kinase, regulatory subunit; Cell cycle regulation
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component: nucleus
Molecular Function: protein dimerization activity; DNA binding; metal ion binding
Biological Process: negative regulation of cell proliferation; response to stress; signal transduction
Research Articles on PRKRIR
Similar Products
Product Notes
The PRKRIR prkrir (Catalog #AAA9213788) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 102-130. The PRKRIR Antibody (N-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PRKRIR can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the PRKRIR prkrir for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PRKRIR, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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