Rabbit Presenilin 1 Polyclonal Antibody | anti-PSEN1 antibody
Presenilin 1 Antibody Affinity Purified
ELISA: 1:10,000
Immunoprecipitation: 1:150
Western Blot: 1:500
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
NCBI and Uniprot Product Information
NCBI Description
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Uniprot Description
PSEN1: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function. Five alternative splice isoforms have been identified.
Protein type: Mitochondrial; Membrane protein, multi-pass; Cell surface; Membrane protein, integral; EC 3.4.23.-; Protease
Chromosomal Location of Human Ortholog: 14q24.3
Cellular Component: axon; cell junction; cell soma; cell surface; centrosome; ciliary rootlet; cytoplasmic vesicle; dendritic shaft; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; growth cone; integral to membrane; integral to plasma membrane; kinetochore; lipid raft; lysosomal membrane; membrane; mitochondrial inner membrane; mitochondrion; neuromuscular junction; nuclear membrane; nuclear outer membrane; nucleus; plasma membrane; rough endoplasmic reticulum; smooth endoplasmic reticulum
Molecular Function: aspartic-type endopeptidase activity; beta-catenin binding; cadherin binding; calcium channel activity; endopeptidase activity; PDZ domain binding; protein binding
Biological Process: activation of MAPKK activity; amyloid precursor protein catabolic process; autophagic vacuole formation; beta-amyloid formation; blood vessel development; brain morphogenesis; Cajal-Retzius cell differentiation; cell fate specification; cell-cell adhesion; cerebral cortex cell migration; choline transport; dorsoventral neural tube patterning; embryonic limb morphogenesis; endoplasmic reticulum calcium ion homeostasis; epithelial cell proliferation; heart looping; hemopoietic progenitor cell differentiation; L-glutamate transport; membrane protein ectodomain proteolysis; memory; mitochondrial transport; myeloid dendritic cell differentiation; negative regulation of apoptosis; negative regulation of axonogenesis; negative regulation of epidermal growth factor receptor activity; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of ubiquitin-protein ligase activity; neuron apoptosis; neuron development; neuron migration; Notch receptor processing; Notch signaling pathway; positive regulation of apoptosis; positive regulation of catalytic activity; positive regulation of coagulation; positive regulation of MAP kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of receptor recycling; positive regulation of transcription, DNA-dependent; post-embryonic development; protein amino acid glycosylation; protein processing; protein transport; regulation of phosphorylation; regulation of protein binding; regulation of resting membrane potential; regulation of synaptic plasticity; regulation of synaptic transmission, glutamatergic; response to DNA damage stimulus; response to oxidative stress; skeletal morphogenesis; skin morphogenesis; smooth endoplasmic reticulum calcium ion homeostasis; somitogenesis; synaptic vesicle targeting; T cell activation during immune response; T cell receptor signaling pathway; thymus development; Wnt receptor signaling pathway through beta-catenin
Disease: Acne Inversa, Familial, 3; Alzheimer Disease 3; Cardiomyopathy, Dilated, 1u; Frontotemporal Dementia; Pick Disease Of Brain
Research Articles on PSEN1
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Product Notes
The PSEN1 psen1 (Catalog #AAA544431) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Presenilin 1 Antibody Affinity Purified reacts with Bovine, Cat, Human, Monkey, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's Presenilin 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), IMM, Western Blot (WB). Dot Blot: 1:10,000 ELISA: 1:10,000 Immunoprecipitation: 1:150 Western Blot: 1:500. Researchers should empirically determine the suitability of the PSEN1 psen1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Presenilin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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