Rabbit anti-Human, Rat PRDM10 Polyclonal Antibody | anti-PRDM10 antibody

PRDM10 Polyclonal Antibody

Cat. Num. AAA3007038

• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PRDM10; Polyclonal Antibody; PRDM10 Polyclonal Antibody; PR domain zinc finger protein 10; PR domain-containing protein 10; Tristanin; KIAA1231; PFM7; TRIS; anti-PRDM10 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PRDM10 polyclonal antibody detects endogenous levels of PRDM10 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 1160

• Applicable Applications for anti-PRDM10 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human PRDM10
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of PRDM10 pAb at 1:500 dilutionLane1:The Testis tissue lysate of Rat (40ug) Lane2:A375 whole cell lysate (40ug) Lane3:A2780 whole cell lysate (40ug) Lane4:SGC7901 whole cell lysate (40ug))

Related Product Information for anti-PRDM10 antibody

The PR-domain containing proteins (PRDMs) have a common involvement in the modulation of gene activities. A PR-domain family member usually produces two products, which differ by the presence or absence of the PR domain. The PR-plus product is underexpressed or disrupted, whereas the PR-minus product is present or overexpressed in cancer cells. This imbalance in the amount of the two products, which is a result of either genetic or epigenetic events, appears to be a determining cause of malignancy. PRDM10 (PR domain containing 10), also known as PFM7 or TRIS, is a 1, 147 amino acid protein that contains ten C2H2-type zinc fingers and one SET domain. Existing as six alternatively spliced isoforms, PRDM10 localizes nucleus and may be involved in transcriptional regulation. PRDM10 may also play a role in the development of the central nerve system, as well as in the pathogenesis of neuronal storage disease.

NCBI and Uniprot Product Information

• NCBI GI #: 41349458
• NCBI Accession #: NP_064613.2
• NCBI GenBank Nucleotide #: NP_064613.2
• UniProt Accession #: Q9NQV6
• Molecular Weight: ~ 130kDa
• NCBI Official Full Name: PR domain zinc finger protein 10 isoform 1
• UniProt Protein Name: PR domain zinc finger protein 10
• Protein Family: PR domain zinc finger protein
• UniProt Gene Name: PRDM10
• UniProt Synonym Gene Names: KIAA1231; PFM7; TRIS

Uniprot Description

PRDM10: May be involved in transcriptional regulation. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Transcription regulation

Chromosomal Location of Human Ortholog: 11q24.3

Cellular Component: nucleus

Molecular Function: DNA binding; metal ion binding; methyltransferase activity; protein binding

Biological Process: methylation; regulation of transcription, DNA-templated; transcription, DNA-dependent