Mouse anti-Human PRCP Polyclonal Antibody | anti-Prcp antibody

PRCP (PCP, Lysosomal Pro-X Carboxypeptidase, Angiotensinase C, Lysosomal Carboxypeptidase C, Proline Carboxypeptidase, Prolylcarboxypeptidase, MGC2202)

Cat. Num. AAA645929

• Gene Names: Prcp; PCP; HUMPCP; AI451719; 2510048K03Rik; 2610104A14Rik
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PRCP; Polyclonal Antibody; PRCP (PCP; Lysosomal Pro-X Carboxypeptidase; Angiotensinase C; Lysosomal Carboxypeptidase C; Proline Carboxypeptidase; Prolylcarboxypeptidase; MGC2202); Anti -PRCP (PCP; anti-Prcp antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PRCP.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH

• Applicable Applications for anti-Prcp antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human PRCP, aa1-496 (NP_005031.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PRCP expression in transfected 293T cell line by PRCP polyclonal antibody. Lane 1: PRCP transfected lysate (54.56kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-Prcp antibody

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].

Product Categories/Family for anti-Prcp antibody

Antibodies; Abs to Enzymes; Carboxypeptidase

NCBI and Uniprot Product Information

• NCBI GI #: 32967631
• NCBI GeneID: 72461
• UniProt Accession #: Q7TMR0; Q3TLW3; Q3V302; Q8BKK3; Q8R0T8; Q9D049
• Molecular Weight: 55,027 Da
• NCBI Official Full Name: Prcp protein
• NCBI Official Synonym Full Names: prolylcarboxypeptidase (angiotensinase C)
• NCBI Official Symbol: Prcp
• NCBI Official Synonym Symbols: PCP; HUMPCP; AI451719; 2510048K03Rik; 2610104A14Rik
• NCBI Protein Information: lysosomal Pro-X carboxypeptidase; proline carboxypeptidase
• UniProt Protein Name: Lysosomal Pro-X carboxypeptidase
• Protein Family: Lysosomal Pro-X carboxypeptidase
• UniProt Gene Name: Prcp
• UniProt Synonym Gene Names: PRCP
• UniProt Entry Name: PCP_MOUSE

Uniprot Description

Function: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH

By similarity.

Catalytic activity: Cleavage of a -Pro-|-Xaa bond to release a C-terminal amino acid.

Subunit structure: Homodimer

By similarity.

Subcellular location: Lysosome

By similarity.

Sequence similarities: Belongs to the peptidase S28 family.