Rabbit PPP2R5B Polyclonal Antibody | anti-PPP2R5B antibody
PPP2R5B Antibody
Gene Names
PPP2R5B; B56B; PR61B
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
PPP2R5B; Polyclonal Antibody; PPP2R5B Antibody; 2A5B_HUMAN; B56B; Beta isoform of regulatory subunit B56 protein phosphatase 2A; FLJ35411; PP2A B subunit B' beta isoform; PP2A B subunit B56 beta isoform; PP2A B subunit isoform B' beta; PP2A B subunit isoform B''-beta; PP2A B subunit isoform B56-beta; PP2A B subunit isoform PR61-beta; PP2A B subunit isoform R5-beta; PP2A B subunit PR61 beta isoform; PP2A B subunit R5 beta isoform; PR 61B; PR61B; Protein phosphatase 2 regulatory subunit B (B56) beta; Protein phosphatase 2 regulatory subunit B (B56) beta isoform; Protein phosphatase 2 regulatory subunit B' beta; Protein phosphatase 2 regulatory subunit B' beta isoform; Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit beta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; anti-PPP2R5B antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
PPP2R5B Antibody detects endogenous levels of total PPP2R5B.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PPP2R5B antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
Belongs to the phosphatase 2A regulatory subunit B56 family.
Post Translational Modifications
Ubiquitinated by E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation.
Subunit Structure
Component of the serine/threonine-protein phosphatase 2A complex (PP2A). This complex consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant scaffold subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1. Interacts with AKT1. Interacts with CUL3 and KLHL15; this interaction leads to proteasomal degradation.
Tissue Specificity
Highest expression in brain.
Function
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
57,393 Da
NCBI Official Full Name
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
NCBI Official Synonym Full Names
protein phosphatase 2, regulatory subunit B', beta
NCBI Official Symbol
PPP2R5B
NCBI Official Synonym Symbols
B56B; PR61B
NCBI Protein Information
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform; PP2A B subunit isoform B'-beta; PP2A B subunit isoform R5-beta; PP2A B subunit isoform B56-beta; PP2A B subunit isoform PR61-beta; protein phosphatase 2, regulatory subunit B'
UniProt Protein Name
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Protein Family
UniProt Gene Name
PPP2R5B
UniProt Entry Name
2A5B_HUMAN
Similar Products
Product Notes
The PPP2R5B ppp2r5b (Catalog #AAA9629698) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PPP2R5B Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PPP2R5B can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the PPP2R5B ppp2r5b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPP2R5B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
