Rabbit anti-Human PPP1R2P3 Polyclonal Antibody | anti-PPP1R2 antibody

PPP1R2P3 (Putative Protein Phosphatase Inhibitor 2-like Protein 3, Protein Phosphatase 1, Regulatory Subunit 2 Pseudogene 3, MGC87149)

Cat. Num. AAA642952

• Gene Names: PPP1R2; IPP2; IPP-2
• Reactivity: Human
• Applications: Immunoprecipitation
• Purity: Serum; Serum
• Synonyms: PPP1R2P3; Polyclonal Antibody; PPP1R2P3 (Putative Protein Phosphatase Inhibitor 2-like Protein 3; Protein Phosphatase 1; Regulatory Subunit 2 Pseudogene 3; MGC87149); Anti -PPP1R2P3 (Putative Protein Phosphatase Inhibitor 2-like Protein 3; anti-PPP1R2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PPP1R2P3.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid.
• Sequence: MAASTASHRPIKGILKNKTSTTSSMVASAEQPRRSVDEELSKKSQKWDEINILATYHPADKGYGLMKIDEPSPPYHSMMGDDEDACRDTETTEAMAPGILAKKLAAAEGLEPKYRIQEQESSGEEDSDLSPEEREKKRQFEMRRKLHYNEGLNIKLARQLISKDLHDDDEDEEMLETADGESMNTEESNQGSTPSDQQQNKLRSS

• Applicable Applications for anti-PPP1R2 antibody: Immunoprecipitation (IP)
• Application Notes: Suitable for use in Immunoprecipitation.
• Immunogen: Full length human PPP1R2P3, aa1-205 (AAH66922.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunoprecipitation (IP)

(Immunoprecipitation of PPP1R2P3 transfected lysate using PPP1R2P3 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with PPP1R2P3 mouse polyclonal antibody.)

Related Product Information for anti-PPP1R2 antibody

Inhibitor of protein-phosphatase 1.

Product Categories/Family for anti-PPP1R2 antibody

Antibodies; Abs to Enzymes; Phosphatase

NCBI and Uniprot Product Information

• NCBI GI #: 5453946
• NCBI GeneID: 5504
• NCBI Accession #: NP_006232.1
• NCBI GenBank Nucleotide #: NM_006241.4
• UniProt Accession #: P41236
• Molecular Weight: 23,015 Da
• NCBI Official Full Name: protein phosphatase inhibitor 2
• NCBI Official Synonym Full Names: protein phosphatase 1, regulatory (inhibitor) subunit 2
• NCBI Official Symbol: PPP1R2
• NCBI Official Synonym Symbols: IPP2; IPP-2
• NCBI Protein Information: protein phosphatase inhibitor 2; phosphoprotein phosphatase
• UniProt Protein Name: Protein phosphatase inhibitor 2
• Protein Family: Protein phosphatase inhibitor
• UniProt Gene Name: PPP1R2
• UniProt Synonym Gene Names: IPP2; IPP-2
• UniProt Entry Name: IPP2_HUMAN

Uniprot Description

PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.

Protein type: Inhibitor; Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q29

Molecular Function: protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; negative regulation of catalytic activity; regulation of signal transduction; regulation of phosphoprotein phosphatase activity