Rabbit PPP1R2 Polyclonal Antibody | anti-PPP1R2 antibody

PPP1R2 (Phospho-Ser120/Ser121) Antibody

Cat. Num. AAA9406538

• Gene Names: PPP1R2; IPP2; IPP-2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Synonyms: PPP1R2; Polyclonal Antibody; PPP1R2 (Phospho-Ser120/Ser121) Antibody; I-2; IPP-2; IPP2; Protein phosphatase inhibitor 2; anti-PPP1R2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of PPP1R2 only when phosphorylated at serine 120 and serine 121.
• Purity/Purification: Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 205

• Applicable Applications for anti-PPP1R2 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50~1:100
• Immunogen Type: peptide
• Immunogen Description: Peptide sequence around phosphorylation site of serine 120 and serine 121 (Q-E-S(p)-S(p)-GE) derived from Human PPP1R2.
• Modification: Phospho-Ser120/Ser121
• Target Name: PPP1R2
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human heart tissue using PPP1R2 (Phospho-Ser120+Ser121) antibody. The picture on the right is treated with the synthesized peptide.)

Related Product Information for anti-PPP1R2 antibody

Inhibitor of protein-phosphatase 1.

Product Categories/Family for anti-PPP1R2 antibody

Phospho-specific Ab

NCBI and Uniprot Product Information

• NCBI GI #: 5453946
• NCBI GeneID: 5504
• NCBI Accession #: NP_006232.1
• NCBI GenBank Nucleotide #: NM_006241.7
• UniProt Accession #: P41236
• Molecular Weight: 23,015 Da
• NCBI Official Full Name: protein phosphatase inhibitor 2 isoform 2
• NCBI Official Synonym Full Names: protein phosphatase 1, regulatory (inhibitor) subunit 2
• NCBI Official Symbol: PPP1R2
• NCBI Official Synonym Symbols: IPP2; IPP-2
• NCBI Protein Information: protein phosphatase inhibitor 2
• UniProt Protein Name: Protein phosphatase inhibitor 2
• Protein Family: Protein phosphatase inhibitor
• UniProt Gene Name: PPP1R2
• UniProt Synonym Gene Names: IPP2; IPP-2
• UniProt Entry Name: IPP2_HUMAN

Uniprot Description

PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.

Protein type: Protein phosphatase, regulatory subunit; Inhibitor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q29

Molecular Function: protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; negative regulation of catalytic activity; regulation of signal transduction; regulation of phosphoprotein phosphatase activity