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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human liver cancer MBS7044129 at dilution 1:100)

Rabbit anti-Human PPIL2 Polyclonal Antibody | anti-PPIL2 antibody

PPIL2 Antibody

Gene Names
PPIL2; CYC4; CYP60; UBOX7; Cyp-60; hCyP-60
Reactivity
Human
Applications
ELISA, Immunohistochemistry
Purity
Antigen Affinity Purified
Synonyms
PPIL2; Polyclonal Antibody; PPIL2 Antibody; Peptidyl-prolyl cis-trans isomerase-like 2Curated; CYC4; anti-PPIL2 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purified
Form/Format
Liquid
Sequence Length
520
Applicable Applications for anti-PPIL2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
Recommended dilution: IHC: 1:20-1:200
Species
Human
Immunogen
Recombinant human Peptidyl-prolyl cis-trans isomerase-like 2 protein (N-260AA)
Conjugate
Non-conjugated
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-86396 / sc-86398
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver cancer MBS7044129 at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human liver cancer MBS7044129 at dilution 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer MBS7044129 at dilution 1:100)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded human prostate cancer MBS7044129 at dilution 1:100)
Related Product Information for anti-PPIL2 antibody
May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins (By similarity). May also function as a chaperone, playing a role in transport to the cell membrane of BSG for instance (PubMed:15946952). May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
59,458 Da
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase-like 2 isoform a
NCBI Official Synonym Full Names
peptidylprolyl isomerase like 2
NCBI Official Symbol
PPIL2
NCBI Official Synonym Symbols
CYC4; CYP60; UBOX7; Cyp-60; hCyP-60
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase-like 2
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase-like 2
UniProt Gene Name
PPIL2
UniProt Synonym Gene Names
hCyP-60
UniProt Entry Name
PPIL2_HUMAN

NCBI Description

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Description

PPIL2: a peptidylprolyl isomerase (PPIase) of the cyclophilin-type family. PPIases accelerate the folding of proteins by catalyzing the cis-trans isomerization of proline imidic peptide bonds. Two alternatively-spliced isoforms have been described.

Protein type: Ubiquitin ligase; Isomerase; Ligase; EC 5.2.1.8; Spliceosome; Ubiquitin conjugating system; Cyclophilin

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: cytoplasm; Golgi lumen; nucleoplasm; nucleus; plasma membrane

Molecular Function: peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: leukocyte migration; protein polyubiquitination

Research Articles on PPIL2

Similar Products

Product Notes

The PPIL2 ppil2 (Catalog #AAA7044129) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PPIL2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PPIL2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Recommended dilution: IHC: 1:20-1:200. Researchers should empirically determine the suitability of the PPIL2 ppil2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PPIL2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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