Rabbit anti-Human, Mouse PPFIA2 Polyclonal Antibody | anti-PPFIA2 antibody

PPFIA2, ID (PPFIA2, Liprin-alpha-2, Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (Azide free) (HRP)

Cat. Num. AAA6336218

• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: PPFIA2; Polyclonal Antibody; ID (PPFIA2; Liprin-alpha-2; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (Azide free) (HRP); Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2; anti-PPFIA2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PPFIA2. Species Crossreactivity: mouse
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 1257

• Applicable Applications for anti-PPFIA2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 571-599 in the central region of human PPFIA2, UniProt Accession #O75334.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in mouse liver tissue lysates (35ug/lane) usingMBS641149.This demonstrates that MBS641149 detected the PPFIA2 protein (arrow).)

Related Product Information for anti-PPFIA2 antibody

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein is most closely related to PPFIA1, a liprin family member known to interact with the protein phosphatase LAR. The expression of this gene is found to be downregulated by androgens in a prostate cancer cell line.

Product Categories/Family for anti-PPFIA2 antibody

Antibodies; Enzymes; Phosphatase

References

1. Rose, J. Phd, et al. Mol. Med. (2010). In press 2. Ko, J., et al. J. Biol. Chem. 278(43):42377-42385(2003). 3. Ko, J., et al. J. Neurosci. 23(5):1667-1677(2003). 4. Fujinami, K., et al. Int. J. Mol. Med. 10(2):173-176(2002). 5. Wyszynski, M., et al. Neuron 34(1):39-52(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 29171755
• NCBI GeneID: 8499
• NCBI Accession #: NP_003616.2
• NCBI GenBank Nucleotide #: NP_003616.2
• UniProt Accession #: O75334
• NCBI Official Full Name: liprin-alpha-2 isoform a
• NCBI Official Synonym Full Names: PTPRF interacting protein alpha 2
• NCBI Official Symbol: PPFIA2
• NCBI Protein Information: liprin-alpha-2
• UniProt Protein Name: Liprin-alpha-2
• Protein Family: Liprin
• UniProt Gene Name: PPFIA2
• UniProt Synonym Gene Names: PTPRF-interacting protein alpha-2
• UniProt Entry Name: LIPA2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]