Western Blot (WB)
(Western blot analysis of extracts from K562 cells and COS-7 cells, using PP4R2 antibody.)
Rabbit anti-Human, Mouse PP4R2 Polyclonal Antibody | anti-PP4R2 antibody
PP4R2 Antibody
Gene Names
PPP4R2; PP4R2
Reactivity
Human, Mouse
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
PP4R2; Polyclonal Antibody; PP4R2 Antibody; MGC131930; protein phosphatase 4; regulatory subunit 2; anti-PP4R2 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Specificity
The antibody detects endogenous levels of total PP4R2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
417
Applicable Applications for anti-PP4R2 antibody
Western Blot (WB)
Application Notes
Western blotting: 1:500~1:3000
Immunogen Type
Peptide
Immunogen Description
Synthesized peptide derived from internal of human PP4R2.
Target Name
PP4R2
Preparation and Storage
Store at -20 degree C
Western Blot (WB)
(Western blot analysis of extracts from K562 cells and COS-7 cells, using PP4R2 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from K562 cells and COS-7 cells, using PP4R2 antibody.)
Related Product Information for anti-PP4R2 antibody
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.Hastie C.J., Biochem. J. 347:845-855(2000).Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases
Product Categories/Family for anti-PP4R2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
40,249 Da
NCBI Official Full Name
serine/threonine-protein phosphatase 4 regulatory subunit 2
NCBI Official Synonym Full Names
protein phosphatase 4, regulatory subunit 2
NCBI Official Symbol
PPP4R2
NCBI Official Synonym Symbols
PP4R2
NCBI Protein Information
serine/threonine-protein phosphatase 4 regulatory subunit 2
UniProt Protein Name
Serine/threonine-protein phosphatase 4 regulatory subunit 2
UniProt Gene Name
PPP4R2
UniProt Entry Name
PP4R2_HUMAN
Uniprot Description
PPP4R2: a protein of unknown function.
Protein type: Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 3p13
Cellular Component: nucleoplasm; centrosome; cytoplasm; nucleus
Molecular Function: protein binding, bridging; protein binding; protein phosphatase type 4 regulator activity
Biological Process: regulation of catalytic activity; RNA splicing; protein modification process; hemopoietic progenitor cell differentiation; mRNA processing
Research Articles on PP4R2
Similar Products
Product Notes
The PP4R2 ppp4r2 (Catalog #AAA9407974) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PP4R2 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PP4R2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:3000. Researchers should empirically determine the suitability of the PP4R2 ppp4r2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PP4R2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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