Testing Data
(The TFact HOXD10 DNA-Binding ELISA detects active HOXD10 in Hela and Jurkat Nuclear Extract. The Hela and Jurkat cells were grown 3 days in DMEM and RPMI 1640 with 10% FBS and harvested for nuclear extract.)
HOXD10 elisa kit
HOXD10 TFact DNA-Binding ELISA Kit
Testing Data
(The TFact HOXD10 DNA-Binding ELISA detects active HOXD10 in Hela and Jurkat Nuclear Extract. The Hela and Jurkat cells were grown 3 days in DMEM and RPMI 1640 with 10% FBS and harvested for nuclear extract.)
Testing Data
(The TFact HOXD10 DNA-Binding ELISA detects active HOXD10 in Hela and Jurkat Nuclear Extract. The Hela and Jurkat cells were grown 3 days in DMEM and RPMI 1640 with 10% FBS and harvested for nuclear extract.)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008]
Uniprot Description
HOXD10: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXD10 are a cause of congenital vertical talus (CVT); also known as rocker-bottom foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity. Belongs to the Abd-B homeobox family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytosol; nucleoplasm
Molecular Function: chromatin binding
Biological Process: adult locomotory behavior; anterior/posterior pattern specification; embryonic limb morphogenesis; embryonic skeletal morphogenesis; forelimb morphogenesis; hindlimb morphogenesis; neuromuscular process; peripheral nervous system neuron development; positive regulation of transcription from RNA polymerase II promoter; proximal/distal pattern formation; single fertilization; skeletal muscle tissue development; spinal cord motor neuron cell fate specification; transcription from RNA polymerase II promoter
Disease: Vertical Talus, Congenital
Research Articles on HOXD10
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Product Notes
The Human, Mouse, Rat HOXD10 hoxd10 (Catalog #AAA9502195) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9502195 ELISA Kit recognizes Human, Mouse, Rat HOXD10. It is sometimes possible for the material contained within the vial of "HOXD10, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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