Western Blot (WB)
(PP1R14C Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PP1R14C antibody detected the PP1R14C protein (arrow).)
Rabbit anti-Human, mouse PP1R14C Polyclonal Antibody | anti-PPP1R14C antibody
PP1R14C Antibody (C-term)
Western Blot (WB)
(PP1R14C Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PP1R14C antibody detected the PP1R14C protein (arrow).)
Western Blot (WB)
(PP1R14C Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the PP1R14C antibody detected the PP1R14C protein (arrow).)
Immunohistochemistry (IHC)
(PP1R14C Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PP1R14C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(PP1R14C Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PP1R14C Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
balance of protein kinase and phosphatase activities. Protein
phosphatase-1 (PP1; see MIM 176875) is a signal-transducing
phosphatase that influences neuronal activity, protein synthesis,
metabolism, muscle contraction, and cell division. PPP1R14C is an
inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by
OMIM].
Scholz, S.W., et al. Ann. Neurol. 65(5):610-614(2009)
Burgner, D., et al. PLoS Genet. 5 (1), E1000319 (2009) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Liu, Q.R., et al. J. Biol. Chem. 277(15):13312-13320(2002)
NCBI and Uniprot Product Information
NCBI Description
The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]
Uniprot Description
KEPI: Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family.
Protein type: Protein phosphatase, regulatory subunit; Inhibitor
Chromosomal Location of Human Ortholog: 6q24.3-q25.3
Cellular Component: membrane; cytoplasm
Molecular Function: type 1 serine/threonine specific protein phosphatase inhibitor activity
Biological Process: regulation of phosphorylation; negative regulation of catalytic activity
Research Articles on PPP1R14C
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Product Notes
The PPP1R14C ppp1r14c (Catalog #AAA9214086) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 126-155. The PP1R14C Antibody (C-term) reacts with Human, mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PP1R14C can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB). WB~~1:1000. Researchers should empirically determine the suitability of the PPP1R14C ppp1r14c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PP1R14C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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