Rabbit POP1 Polyclonal Antibody | anti-POP1 antibody

POP1 Rabbit Polyclonal

Cat. Num. AAA7602873

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: POP1; Polyclonal Antibody; POP1 Rabbit Polyclonal; anti-POP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 126

• Applicable Applications for anti-POP1 antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Immunogen: Processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7602873 (POP1 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 1770490
• NCBI GeneID: 10940
• UniProt Accession #: Q99575; Q15037; A8K5W9
• Molecular Weight: 114,709 Da
• NCBI Official Full Name: Pop1, partial
• NCBI Official Synonym Full Names: POP1 homolog, ribonuclease P/MRP subunit
• NCBI Official Symbol: POP1
• NCBI Protein Information: ribonucleases P/MRP protein subunit POP1
• UniProt Protein Name: Ribonucleases P/MRP protein subunit POP1
• Protein Family: Ribonucleases P/MRP protein
• UniProt Gene Name: POP1
• UniProt Synonym Gene Names: KIAA0061; hPOP1
• UniProt Entry Name: POP1_HUMAN

NCBI Description

This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

Uniprot Description

POP1: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP. Defects in POP1 may be the cause of a severe skeletal dysplasia reminiscent of anauxetic dysplasia. Affected individuals show severe growth retardation of prenatal onset, a bone dysplasia affecting the epiphyses and metaphyses of the long bones particularly in the lower limbs, and abnormalities of the spine including irregularly shaped vertebral bodies and marked cervical spine instability.

Protein type: Ribonuclease; Nucleolus; RNA processing; EC 3.1.26.5

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: extracellular space; nucleolar ribonuclease P complex; nucleoplasm; ribonuclease MRP complex

Molecular Function: protein binding; ribonuclease MRP activity; ribonuclease P activity

Biological Process: tRNA 5'-leader removal; tRNA catabolic process; tRNA processing