Rabbit anti-Human GNAI3 Polyclonal Antibody | anti-GNAI3 antibody

GNAI3 Polyclonal Antibody

Cat. Num. AAA2554923

• Gene Names: GNAI3; 87U6; ARCND1
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purification
• Synonyms: GNAI3; Polyclonal Antibody; GNAI3 Polyclonal Antibody; 87U6; FLJ26559; G protein alpha inhibiting 3; G(i) alpha 3; G(i) alpha-3; Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3; Guanine nucleotide binding protein G(k) alpha subunit; Guanine nucleotide-binding protein G(k) subunit alpha; OTTHUMP00000013368; anti-GNAI3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 354

• Applicable Applications for anti-GNAI3 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant protein of human GNAI3
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines, using GNAI3 antibody.)

Related Product Information for anti-GNAI3 antibody

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway.

Product Categories/Family for anti-GNAI3 antibody

Cancer; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 5729850
• NCBI GeneID: 2773
• NCBI Accession #: NP_006487.1
• NCBI GenBank Nucleotide #: NM_006496.3
• UniProt Accession #: P08754; P17539; Q5TZX1
• Molecular Weight: Calculated: 40kDa; Observed: 45kDa
• NCBI Official Full Name: guanine nucleotide-binding protein G(k) subunit alpha
• NCBI Official Synonym Full Names: G protein subunit alpha i3
• NCBI Official Symbol: GNAI3
• NCBI Official Synonym Symbols: 87U6; ARCND1
• NCBI Protein Information: guanine nucleotide-binding protein G(k) subunit alpha
• UniProt Protein Name: Guanine nucleotide-binding protein G(k) subunit alpha
• UniProt Gene Name: GNAI3

NCBI Description

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012]

Uniprot Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541, PubMed:19478087). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (PubMed:19478087). Stimulates the activity of receptor-regulated K+ channels (PubMed:2535845). The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division (PubMed:17635935).