Western Blot (WB)
(POLI Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the POLI antibody detected the POLI protein (arrow).)
Rabbit anti-Human POLI Polyclonal Antibody | anti-POLI antibody
POLI Antibody (C-term)
Western Blot (WB)
(POLI Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the POLI antibody detected the POLI protein (arrow).)
Western Blot (WB)
(POLI Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the POLI antibody detected the POLI protein (arrow).)
Immunohistochemistry (IHC)
(POLI Antibody (C-term) (MBS9210776)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of POLI Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(POLI Antibody (C-term) (MBS9210776)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of POLI Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010)
Kazakov, A.A., et al. Biochemistry Mosc. 75(7):905-911(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Monsees, G.M., et al. Breast Cancer Res. Treat. (2010) In press :
NCBI and Uniprot Product Information
Uniprot Description
POLI: Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. Belongs to the DNA polymerase type-Y family.
Protein type: EC 2.7.7.7; Transferase; DNA repair, damage
Chromosomal Location of Human Ortholog: 18q21.1
Cellular Component: nucleoplasm; intracellular membrane-bound organelle; intracellular; nucleus
Molecular Function: protein binding; metal ion binding; damaged DNA binding; DNA-directed DNA polymerase activity
Biological Process: DNA repair; DNA replication
Research Articles on POLI
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Product Notes
The POLI poli (Catalog #AAA9210776) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 673-701. The POLI Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's POLI can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the POLI poli for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "POLI, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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