Mouse anti-Human POC1A Polyclonal Antibody | anti-POC1A antibody

POC1A (POC1 Centriolar Protein Homolog A, Pix2, WD Repeat-containing Protein 51A, WDR51A, SOFT)

Cat. Num. AAA647418

• Gene Names: POC1A; PIX2; SOFT; WDR51A
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: POC1A; Polyclonal Antibody; POC1A (POC1 Centriolar Protein Homolog A; Pix2; WD Repeat-containing Protein 51A; WDR51A; SOFT); Anti -POC1A (POC1 Centriolar Protein Homolog A; anti-POC1A antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human WDR51A.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQLDVLTQTVSILEQRLTLTEDKLKQCLENQQLIMQRATP*

• Applicable Applications for anti-POC1A antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human WDR51A, aa1-365 (AAH07417).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of WDR51A expression in transfected 293T cell line by WDR51A polyclonal antibody. Lane 1: WDR51A transfected lysate (40.15kD). Lane 2: Non-transfected lysate.)

Product Categories/Family for anti-POC1A antibody

Antibodies; Abs to WD Repeat Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 239787764
• NCBI GeneID: 25886
• NCBI Accession #: NP_001155053.1
• NCBI GenBank Nucleotide #: NM_001161581.1
• UniProt Accession #: Q8NBT0; Q0VDF8; Q2TAK6; Q96IK6; Q9UFJ8; A4FUW4; E9PFC6
• Molecular Weight: 45,009 Da
• NCBI Official Full Name: POC1 centriolar protein homolog A isoform 3
• NCBI Official Synonym Full Names: POC1 centriolar protein A
• NCBI Official Symbol: POC1A
• NCBI Official Synonym Symbols: PIX2; SOFT; WDR51A
• NCBI Protein Information: POC1 centriolar protein homolog A; WD repeat domain 51A; WD repeat-containing protein 51A
• UniProt Protein Name: POC1 centriolar protein homolog A
• Protein Family: POC1 centriolar protein
• UniProt Gene Name: POC1A
• UniProt Synonym Gene Names: WDR51A
• UniProt Entry Name: POC1A_HUMAN

NCBI Description

POC1 proteins contain an N-terminal WD40 domain and a C-terminal coiled coil domain and are part of centrosomes. They play an important role in basal body and cilia formation. This gene encodes one of the two POC1 proteins found in humans. Mutations in this gene result in short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) syndrome. [provided by RefSeq, Sep 2012]

Uniprot Description

Function: Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Required for ciliogenesis. Ref.7

Subcellular location: Cytoplasm › cytoskeleton › microtubule organizing center › centrosome › centriole. Cytoplasm › cytoskeleton › cilium basal body. Note: Component of both mother and daughter centrioles. Ref.5 Ref.6 Ref.7

Involvement in disease: Short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) [MIM:614813]: A syndrome characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed.Note: The disease is caused by mutations affecting the gene represented in this entry. Cells derived from affected individuals have abnormal mitotic mechanics with multipolar spindles, in addition to clearly impaired ciliogenesis. Ref.8 Ref.9

Sequence similarities: Belongs to the WD repeat POC1 family.Contains 7 WD repeats.

Sequence caution: The sequence AAI19694.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.The sequence CAB56021.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.