Western Blot (WB)
(Western Blot (WB) analysis of PNPLA2 polyclonal antibody)
Rabbit PNPLA2 Polyclonal Antibody | anti-PNPLA2 antibody
PNPLA2 Polyclonal Antibody
Gene Names
PNPLA2; ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
PNPLA2; Polyclonal Antibody; PNPLA2 Polyclonal Antibody; Adipose triglyceride lipase; ATGL; ATGL DESNUTRIN; Calcium independent phospholipase A2; Calcium-independent phospholipase A2; Desnutrin; FP17548; IPLA2 zeta; IPLA2-zeta; PATATIN LIKE PHOSPHOLIPASE DOMAIN CONTAINING PROTEIN 2; Patatin-like phospholipase domain-containing protein 2; PEDF R; PHOSPHOLIPASE A2 CALCIUM INDEPENDENT ZETA; Pigment epithelium derived factor; Pigment epithelium-derived factor; plpl; plpl2; PLPL2_HUMAN; Pnpla2; Transport secretion protein 2; Transport secretion protein 2.2; Transport-secretion protein 2; Triglyceride hydrolase; TTS 2.2; TTS2; TTS2.2; ZETA; anti-PNPLA2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
PNPLA2 polyclonal antibody detects endogenous levels of PNPLA2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
504
Applicable Applications for anti-PNPLA2 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
Recombinant full length Human PNPLA2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of PNPLA2 polyclonal antibody)
Western Blot (WB)
(Western Blot (WB) analysis of PNPLA2 polyclonal antibody)
Related Product Information for anti-PNPLA2 antibody
The Adiponutrin family members, which have been implicated in obesity and diabetes, consist of Adiponutrin (ADPN), GS1, GS2, GS2-like, PNPLA1, and adipose triglyceride lipase (ATGL), also designated Desnutrin or Patatin-like phospholipase domain-containing protein 2 (PLNPA2). AGTL is a 486-amino acid protein that is highly expressed in mouse and human adipose tissue. It contains a highly conserved 180-amino acid N-terminal patatin domain common to plant acyl-hydrolases with a glycine-rich region, an aspartate active site motif, and an active serine hydrolase motif. Along with hormone-sensitive lipase, ATGL catabolizes stored triglycerides in mammalian adipose tissue. The lipase activity of AGTL is dependent upon the presence of an activated serine residue. ADPN and ATGL are oppositely regulated by insulin, where upregulation of ATGl and downregulation of ADPN occurs when fasting.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
~ 55kDa
NCBI Official Full Name
Patatin-like phospholipase domain-containing protein 2
NCBI Official Synonym Full Names
patatin like phospholipase domain containing 2
NCBI Official Symbol
PNPLA2
NCBI Official Synonym Symbols
ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik
NCBI Protein Information
patatin-like phospholipase domain-containing protein 2
UniProt Protein Name
Patatin-like phospholipase domain-containing protein 2
Protein Family
UniProt Gene Name
PNPLA2
UniProt Synonym Gene Names
ATGL; TTS2
NCBI Description
This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]
Uniprot Description
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed:16239926). May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.
Research Articles on PNPLA2
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Product Notes
The PNPLA2 pnpla2 (Catalog #AAA3011416) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PNPLA2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PNPLA2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the PNPLA2 pnpla2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PNPLA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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