Rabbit anti-Mouse, Rat PLXNA4 Polyclonal Antibody | anti-PLXNA4 antibody

PLXNA4 Polyclonal Antibody

Cat. Num. AAA3007061

• Gene Names: PLXNA4; PLEXA4; PLXNA4A; PLXNA4B; FAYV2820; PRO34003
• Reactivity: Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: PLXNA4; Polyclonal Antibody; PLXNA4 Polyclonal Antibody; Plexin-A4; KIAA1550; PLXNA4A; PLXNA4B; UNQ2820; PRO34003; anti-PLXNA4 antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: PLXNA4 polyclonal antibody detects endogenous levels of PLXNA4 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 492

• Applicable Applications for anti-PLXNA4 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human PLXNA4.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of PLXNA4 polyclonal antibody at 1:500 dilutionLane1:sp2/0 whole cell lysate Lane2:PC12 whole cell lysate)

Related Product Information for anti-PLXNA4 antibody

Plexin-A4, also known as PLXNA4 or FAYV2820, is a 1, 894 amino acid singlepass type I membrane protein that contains one sema domain, three PSI domains and four IPT/TIG domains. Belonging to a large family of semaphorin (SEMA) receptors, plexin-A4 forms a complex with neuropilin and, once complexed, can propagate SEMA3A-induced inhibitory signals into neurons and cells, possibly playing a role in early nerve development. Four isoforms of plexin-A4 exist due to alternative splicing events. The gene encoding plexin-A4 maps to human chromosome 7, which houses over 1, 000 genes and comprises nearly 5% of the human genome. Defects in some of the genes localized to chromosome 7 have been linked to osteogenesis imperfecta, Williams-Beuren syndrome, Pendred syndrome, lissencephaly, citrullinemia and Shwachman-Diamond syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 157738647
• NCBI GeneID: 91584
• NCBI Accession #: NP_001099013.1
• NCBI GenBank Nucleotide #: NP_001099013.1
• UniProt Accession #: Q9HCM2
• Molecular Weight: ~ 212kDa
• NCBI Official Full Name: plexin-A4 isoform 3
• NCBI Official Synonym Full Names: plexin A4
• NCBI Official Symbol: PLXNA4
• NCBI Official Synonym Symbols: PLEXA4; PLXNA4A; PLXNA4B; FAYV2820; PRO34003
• NCBI Protein Information: plexin-A4
• UniProt Protein Name: Plexin-A4
• Protein Family: Plexin
• UniProt Gene Name: PLXNA4
• UniProt Synonym Gene Names: KIAA1550; PLXNA4A; PLXNA4B

Uniprot Description

Coreceptor for SEMA3A. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm ().