Immunohistochemistry (IHC)
(Immunochemical staining of human PLVAP in human skin with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human PLVAP Polyclonal Antibody | anti-PLVAP antibody
Anti-PLVAP Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
PLVAP; Polyclonal Antibody; Anti-PLVAP Antibody; Rabbit Polyclonal; PLVAP Antibody; Rabbit PAb; Antigen Affinity Purified; Plasmalemma Vesicle Associated Protein; Anti-FELS Antibody; Anti-gp68 Antibody; Anti-PV-1 Antibody; Anti-PV1 Antibody; anti-PLVAP antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human PLVAP
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-PLVAP antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:500-1:2000
Immunogen
E Coli-derived Human PLVAP fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human PLVAP fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human PLVAP in human skin with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human PLVAP in human skin with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-PLVAP antibody
Plasmalemma vesicle-associated protein (PLVAP, also known as PV-1) is the only protein that forms endothelial diaphragms. Transmembrane PLVAP (plasmalemma vesicle-associated protein) protein is the only known diaphragm component and is necessary for the formation of diaphragms. PLVAP is specifically expressed in endothelial cells in which it localizes to diaphragms of fenestrae, caveolae, and transendothelial channels. PLVAP expression is very low in the normal blood-retinal barrier; however, pathological factors such as high glucose and vascular endothelial growth factor (VEGF) induce its expression, leading to the exacerbation of cellular permeability. Because the new blood vessels are fragile and leaky, PLVAP could be considered a therapeutic target against retinovascular diseases.
References
Nakagami Y, et al. (2019) An anti-plvap antibody suppresses laser-induced choroidal neovascularization in monkeys. Eur J Pharmacol 854 240-246.Herrnberger L, et al. (2012) The role of plasmalemma vesicle-associated protein (plvap) in endothelial cells of schlemm's canal and ocular capillaries. Exp Eye Res 105 27-33.Herrnberger L, et al. (2012) Lack of endothelial diaphragms in fenestrae and caveolae of mutant plvap-deficient mice. Histochem Cell Biol 138 (5): 709-724.Auvinen K, et al. (2019) Fenestral diaphragms and plvap associations in liver sinusoidal endothelial cells are developmentally regulated. Sci Rep 9 (1): 15698.
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Product Notes
The PLVAP (Catalog #AAA8108103) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-PLVAP Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PLVAP can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:500-1:2000. Researchers should empirically determine the suitability of the PLVAP for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLVAP, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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