Rabbit anti-Human PLP2 Polyclonal Antibody | anti-PLP2 antibody

PLP2 (Proteolipid Protein 2, Differentiation-Dependent Protein A4, Intestinal Membrane A4 Protein, PLP2, A4) (MaxLight 490)

Cat. Num. AAA6458236

• Gene Names: PLP2; A4; A4LSB
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: PLP2; Polyclonal Antibody; PLP2 (Proteolipid Protein 2; Differentiation-Dependent Protein A4; Intestinal Membrane A4 Protein; A4) (MaxLight 490); anti-PLP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PLP2. Species Crossreactivity: human
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-PLP2 antibody: Western Blot (WB)
• Application Notes: WB: 1:2000; Applications are based on unconjugated antibody.
• Immunogen: KLH conjugated synthetic peptide corresponding to aa133-166 at the C-terminal region of human PLP2.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Product Categories/Family for anti-PLP2 antibody

Antibodies; Myelin

References

Oliva M.M., et al. Arch. Biochem. Biophys. 302:183-192(1993). Fisher S.E., et al. Genomics 45:340-347(1997). Kimura K., et al. Genome Res. 16:55-65(2006). Ross M.T., et al. Nature 434:325-337(2005). Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).

NCBI and Uniprot Product Information

• NCBI GI #: 4505893
• NCBI GeneID: 5355
• NCBI Accession #: NP_002659.1
• NCBI GenBank Nucleotide #: NM_002668.2
• UniProt Accession #: Q04941; Q32MM8; A6NDT7
• Molecular Weight: 16,691 Da
• NCBI Official Full Name: proteolipid protein 2
• NCBI Official Synonym Full Names: proteolipid protein 2 (colonic epithelium-enriched)
• NCBI Official Symbol: PLP2
• NCBI Official Synonym Symbols: A4; A4LSB
• NCBI Protein Information: proteolipid protein 2; intestinal membrane A4 protein; A4 differentiation-dependent protein; differentiation-dependent protein A4
• UniProt Protein Name: Proteolipid protein 2
• Protein Family: Proteolipid protein
• UniProt Gene Name: PLP2
• UniProt Synonym Gene Names: A4
• UniProt Entry Name: PLP2_HUMAN

NCBI Description

This gene encodes an integral membrane protein that localizes to the endoplasmic reticulum in colonic epithelial cells. The encoded protein can multimerize and may function as an ion channel. A polymorphism in the promoter of this gene may be linked to an increased risk of X-linked mental retardation. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Jan 2010]

Uniprot Description

PLP2: May play a role in cell differentiation in the intestinal epithelium. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass; Cell development/differentiation

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: protein binding; ion transmembrane transporter activity; chemokine binding

Biological Process: cytokine and chemokine mediated signaling pathway; ion transport; chemotaxis