Western Blot (WB)
(Western blotAll lanes: PLP1 antibody at 4ug/mlLane 1: Hela whole cell lysateLane 2: HL60 whole cell lysateLane 3: K562 whole cell lysateLane 4: THP-1 whole cell lysateLane 5: U937 whole cell lysateLane 6: A549 whole cell lysateLane 7: Caco-2 whole cell lysateLane 8: HepG2 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 31, 27 kDaObserved band size: 31 kDa)
Rabbit anti-Human PLP1 Polyclonal Antibody | anti-PLP1 antibody
PLP1 Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Western Blot (WB)
(Western blotAll lanes: PLP1 antibody at 4ug/mlLane 1: Hela whole cell lysateLane 2: HL60 whole cell lysateLane 3: K562 whole cell lysateLane 4: THP-1 whole cell lysateLane 5: U937 whole cell lysateLane 6: A549 whole cell lysateLane 7: Caco-2 whole cell lysateLane 8: HepG2 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 31, 27 kDaObserved band size: 31 kDa)
Western Blot (WB)
(Western blotAll lanes: PLP1 antibody at 4ug/mlLane 1: Hela whole cell lysateLane 2: HL60 whole cell lysateLane 3: K562 whole cell lysateLane 4: THP-1 whole cell lysateLane 5: U937 whole cell lysateLane 6: A549 whole cell lysateLane 7: Caco-2 whole cell lysateLane 8: HepG2 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 31, 27 kDaObserved band size: 31 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human breast cancer using MBS7005540 at dilution of 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human breast cancer using MBS7005540 at dilution of 1:100)
Immunofluorescent (IF)
(Immunofluorescent analysis of Hela cells using MBS7005540 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
Immunofluorescent (IF)
(Immunofluorescent analysis of Hela cells using MBS7005540 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
Uniprot Description
PLP1: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Defects in PLP1 are the cause of leukodystrophy hypomyelinating type 1 (HLD1); also known as Pelizaeus-Merzbacher disease. HLD1 is an X-linked recessive dysmyelinating disorder of the central nervous system in which myelin is not formed properly. It is characterized clinically by nystagmus, spastic quadriplegia, ataxia, and developmental delay. Defects in PLP1 are the cause of spastic paraplegia X- linked type 2 (SPG2). SPG2 is characterized by spastic gait and hyperreflexia. In some patients, complicating features include nystagmus, dysarthria, sensory disturbance, mental retardation, optic atrophy. Belongs to the myelin proteolipid protein family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell surface; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xq22
Cellular Component: integral to membrane; myelin sheath; plasma membrane
Molecular Function: protein binding; structural constituent of myelin sheath; structural molecule activity
Biological Process: astrocyte development; axon ensheathment; cell maturation; inflammatory response; integrin-mediated signaling pathway; long-chain fatty acid biosynthetic process; myelination in the central nervous system; substantia nigra development; synaptic transmission
Disease: Pelizaeus-merzbacher Disease; Spastic Paraplegia 2, X-linked
Research Articles on PLP1
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Product Notes
The PLP1 plp1 (Catalog #AAA7005540) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PLP1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PLP1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) . WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:50-1:200. Researchers should empirically determine the suitability of the PLP1 plp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLP1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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