Goat anti-Human, Mouse Plexin D1 Polyclonal Antibody | anti-PLEXD1 antibody

Plexin D1 (Plexin-D1, PLEXD1, PLXND1, PLXND1 Protein, KIAA0620, MGC75353) (APC)

Cat. Num. AAA6493965

• Gene Names: PLXND1; PLEXD1
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Purified by Immunoaffinity chromatography.
• Synonyms: Plexin D1; Polyclonal Antibody; Plexin D1 (Plexin-D1; PLEXD1; PLXND1; PLXND1 Protein; KIAA0620; MGC75353) (APC); anti-PLEXD1 antibody

• Host: Goat
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PLXND1. Species Crossreactivity: mouse
• Purity/Purification: Purified by Immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-PLEXD1 antibody: FLISA, Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to C-LAEPKKSHRQSH, from PLXND1, at the internal region of human Plexin D1 (NP_055918.2). Species sequence homology: canine, porcine and bovine
• Conjugate: APC
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-PLEXD1 antibody

Plexin D1 is a type I transmembrane protein that is the prototype of the Plexin D subfamily in the Plexin family. It is expressed on multiple tissues including fetal neuronal and endothelial cells. Plexin D1 expression is also induced on tumor vasculature and tumor cells. The 1879aa mature human Plexin D1 contains a large (1225aa) extracellular domain with a 500aa sema domain and three short MRS (Met-related sequences) cysteine-rich motifs. By alternative splicing, multiple Plexin-D1 isoforms may exist. Plexin D1 binds Sema4A to suppress angiogenesis. It also binds Sema3E directly to mediate repulsive vascular vessal guidance. In mouse, this interaction has been shown to be independent of Neuropilin and Sema3A. Over the extracellular region used as immunogen, human Plexin D1 shares 89% and 91% aa identity with the mouse and canine protein, respectively.

Product Categories/Family for anti-PLEXD1 antibody

Antibodies; Plexin; Semaphorin

References

1. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14;307(5707):265-8. Epub 2004 Nov 18.

NCBI and Uniprot Product Information

• NCBI GI #: 157694524
• NCBI GeneID: 23129
• NCBI Accession #: NP_055918.2
• NCBI GenBank Nucleotide #: NM_015103.2
• UniProt Accession #: Q9Y4D7; Q6PJS9; Q8IZJ2; Q9BTQ2; A7E2C6; C9JPZ6
• Molecular Weight: 195,558 Da
• NCBI Official Full Name: plexin-D1
• NCBI Official Synonym Full Names: plexin D1
• NCBI Official Symbol: PLXND1
• NCBI Official Synonym Symbols: PLEXD1
• NCBI Protein Information: plexin-D1
• UniProt Protein Name: Plexin-D1
• UniProt Gene Name: PLXND1
• UniProt Synonym Gene Names: KIAA0620

Uniprot Description

Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Required for normal development of the heart and vasculature (). Mediates anti-angiogenic signaling in response to SEMA3E.