Western Blot (WB)
(22RV1 cells were subjected to SDS PAGE followed by western blot with MBS7602778 (Plexin B2 Antibody) at dilution of 1:1000)
Rabbit Plexin B2 Polyclonal Antibody | anti-Plexin B2 antibody
Plexin B2 Rabbit Polyclonal
Immunogen Affinity Purified
Immunogen Affinity Purified
Western Blot (WB)
(22RV1 cells were subjected to SDS PAGE followed by western blot with MBS7602778 (Plexin B2 Antibody) at dilution of 1:1000)
Western Blot (WB)
(22RV1 cells were subjected to SDS PAGE followed by western blot with MBS7602778 (Plexin B2 Antibody) at dilution of 1:1000)
NCBI and Uniprot Product Information
NCBI Description
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Uniprot Description
PLXNB2: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). Belongs to the plexin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component: cell surface; integral to plasma membrane
Molecular Function: protein binding; semaphorin receptor activity
Biological Process: brain development; negative regulation of cell adhesion; neural tube closure; neuroblast proliferation; positive regulation of axonogenesis; regulation of cell migration; regulation of cell shape; regulation of GTPase activity; regulation of protein amino acid phosphorylation
Research Articles on Plexin B2
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Product Notes
The Plexin B2 plxnb2 (Catalog #AAA7602778) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Plexin B2 Rabbit Polyclonal reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Plexin B2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the Plexin B2 plxnb2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Plexin B2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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