Western Blot (WB)
(Western blot analysis of PLEKHA1 (arrow) using rabbit polyclonal PLEKHA1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PLEKHA1 gene.)
Rabbit anti-Human PLEKHA1 Polyclonal Antibody | anti-PLEKHA1 antibody
PLEKHA1, ID (PLEKHA1, TAPP1, Pleckstrin homology domain-containing family A member 1, Tandem PH domain-containing protein 1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(Western blot analysis of PLEKHA1 (arrow) using rabbit polyclonal PLEKHA1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PLEKHA1 gene.)
Western Blot (WB)
(Western blot analysis of PLEKHA1 (arrow) using rabbit polyclonal PLEKHA1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the PLEKHA1 gene.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]
Uniprot Description
PLEKHA1: Binds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 10q26.13
Cellular Component: nucleoplasm; cytoplasm; plasma membrane
Molecular Function: protein binding; phosphatidylinositol-3,4-bisphosphate binding; PDZ domain binding
Biological Process: estrogen metabolic process; phosphoinositide 3-kinase cascade; negative regulation of protein kinase B signaling cascade; multicellular organism growth; androgen metabolic process; platelet-derived growth factor receptor signaling pathway; palate development; post-embryonic development; B cell receptor signaling pathway; establishment of protein localization; Leydig cell differentiation; skeletal morphogenesis; luteinization; ruffle organization and biogenesis; spermatogenesis
Disease: Macular Degeneration, Age-related, 1
Research Articles on PLEKHA1
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Product Notes
The PLEKHA1 plekha1 (Catalog #AAA6000538) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PLEKHA1, ID (PLEKHA1, TAPP1, Pleckstrin homology domain-containing family A member 1, Tandem PH domain-containing protein 1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PLEKHA1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the PLEKHA1 plekha1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLEKHA1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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