Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded section of Mammary Cancer Tissue)
Rabbit Pleiotrophin Polyclonal Antibody | anti-PTN antibody
Pleiotrophin Antibody
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded section of Mammary Cancer Tissue)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded section of Mammary Cancer Tissue)
Western Blot (WB)
(Lane 1: Rat Brain Tissue Lysate; Lane 2: Rat Kidney Tissue Lysate; Lane 3: Human MCF-7 Cell Lysate; Lane 4: HT-1080 Cell Lysate; Lane 5: SMMC Cell Lysate)
Western Blot (WB)
(Lane 1: Rat Brain Tissue Lysate; Lane 2: Rat Kidney Tissue Lysate; Lane 3: Human MCF-7 Cell Lysate; Lane 4: HT-1080 Cell Lysate; Lane 5: SMMC Cell Lysate)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Description
PTN: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. Belongs to the pleiotrophin family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q33
Cellular Component: extracellular space; endoplasmic reticulum
Molecular Function: heparin binding; growth factor activity; protein phosphatase inhibitor activity
Biological Process: nervous system development; positive regulation of cell division; positive regulation of cell proliferation; negative regulation of catalytic activity; learning; transmembrane receptor protein tyrosine phosphatase signaling pathway; bone mineralization
Research Articles on PTN
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Product Notes
The PTN ptn (Catalog #AAA5312737) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Pleiotrophin can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the PTN ptn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pleiotrophin, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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