Rabbit anti-Human PLCD4 Polyclonal Antibody | anti-plcd4 antibody

PLCD4 (1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase delta-4, hPLCD4, Phosphoinositide Phospholipase C-delta-4, Phospholipase C-delta-4, PLC-delta-4, MGC12837)

Cat. Num. AAA644724

• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: PLCD4; Polyclonal Antibody; PLCD4 (1-phosphatidylinositol 4; 5-bisphosphate Phosphodiesterase delta-4; hPLCD4; Phosphoinositide Phospholipase C-delta-4; Phospholipase C-delta-4; PLC-delta-4; MGC12837); Anti -PLCD4 (1-phosphatidylinositol 4; anti-plcd4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human PLCD4.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES

• Applicable Applications for anti-plcd4 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human PLCD4, aa1-762 (NP_116115.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of PLCD4 expression in transfected 293T cell line by PLCD4 polyclonal antibody. Lane 1: PLCD4 transfected lysate (87.6kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-plcd4 antibody

Phosphatidylinositol-specific phospholipase C (PLC) plays an important role in receptor-mediated signal transduction by generating 2 second messenger molecules, inositol 1,4,5-triphosphate (IP3) and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate (PIP2). PLC comprises a diverse family of enzymes that differ in structure and tissue distribution (Berridge, 1993 [PubMed 8381210]).

Product Categories/Family for anti-plcd4 antibody

Antibodies; Abs to Enzymes; Phospholipase

NCBI and Uniprot Product Information

• NCBI GI #: 80476518
• NCBI GeneID: 735225
• UniProt Accession #: Q32NH8
• Molecular Weight: 87,417 Da
• NCBI Official Full Name: Plcd4 protein
• NCBI Official Synonym Full Names: phospholipase C, delta 4
• NCBI Official Symbol: plcd4
• NCBI Protein Information: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4; PLC-delta-4; phospholipase C-delta-4; phosphoinositide phospholipase C delta-4; phosphoinositide phospholipase C-delta-4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 4; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4
• UniProt Protein Name: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4
• Protein Family: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
• UniProt Gene Name: plcd4
• UniProt Synonym Gene Names: PLC-delta-4
• UniProt Entry Name: PLCD4_XENLA

Uniprot Description

Function: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca2+ from intracellular stores

By similarity.

Catalytic activity: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactor: Binds 3 calcium ions per subunit. Two of the calcium ions are bound to the C2 domain

By similarity.

Subcellular location: Membrane; Peripheral membrane protein

By similarity. Nucleus

By similarity. Cytoplasm

By similarity. Endoplasmic reticulum

By similarity. Note: Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum

By similarity.

Sequence similarities: Contains 1 C2 domain.Contains 3 EF-hand domains.Contains 1 PH domain.Contains 1 PI-PLC X-box domain.Contains 1 PI-PLC Y-box domain.