Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Rabbit anti-Human Plakophilin 2 Polyclonal Antibody | anti-PKP2 antibody
Polyclonal Antibody to Plakophilin 2 (PKP2)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- DGRKAMRRCD GLIDSLVHYV RGTIADYQPD DKATENCVCI LHNLSYQLEA ELPEKYSQNI YIQNRNIQTD NNKSIGCFGS RSRKVKEQYQ DVPMPEEKSN PKGVEWLWHS IVIRMYLSLI AKSVRNYTQE ASLGALQNLT AGSGPMPTSV AQTVVQKESG LQHTRKMLHV GDPSVKKTAI SLLRNLSRNL SLQNEIAKET LPDLVSIIPD TVPSTDLLIE TTASACYTLN NIIQNSYQNA RDLLNTGGIQ KIMAISAGDA
Immunohistochemistry: 5-20ug/mL;1:25-100
Immunocytochemistry: 5-20ug/mL;1:25-100
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Western Blot (WB)
(Western Blot: Sample: Recombinant protein.)
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Brain tissue))
Immunohistochemistry (IHC)
(DAB staining on fromalin fixed paraffin-embedded Brain tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Stomach Tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]
Uniprot Description
plakophilin 2: May play a role in junctional plaques. Defects in PKP2 are the cause of familial arrhythmogenic right ventricular dysplasia type 9 (ARVD9); also known as arrhythmogenic right ventricular cardiomyopathy 9 (ARVC9). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 12p11.21
Cellular Component: adherens junction; cell junction; cornified envelope; desmosome; integral component of membrane; intercalated disc; intercellular junction; intermediate filament; nucleoplasm; nucleus; plasma membrane
Molecular Function: alpha-catenin binding; cadherin binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; intermediate filament binding; ion channel binding; protein binding; protein complex scaffold activity; protein kinase C binding; sodium channel regulator activity
Biological Process: bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cardiac muscle cell action potential; cardiac muscle cell action potential involved in contraction; cell communication by electrical coupling involved in cardiac conduction; cell-cell signaling involved in cardiac conduction; cornification; gap junction assembly; heart development; intermediate filament bundle assembly; keratinization; lipid homeostasis; maintenance of animal organ identity; negative regulation of cell migration; negative regulation of cell proliferation; positive regulation of sodium ion transport; protein localization to plasma membrane; regulation of bicellular tight junction assembly; regulation of heart rate by cardiac conduction; regulation of molecular function; regulation of ventricular cardiac muscle cell action potential; ventricular cardiac muscle cell action potential; ventricular cardiac muscle tissue morphogenesis
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 9
Research Articles on PKP2
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Product Notes
The PKP2 pkp2 (Catalog #AAA2028679) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Plakophilin 2 (PKP2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Plakophilin 2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.2-2ug/mL;1:250-2500 Immunohistochemistry: 5-20ug/mL;1:25-100 Immunocytochemistry: 5-20ug/mL;1:25-100 Optimal working dilutions must be determined by end user. . Researchers should empirically determine the suitability of the PKP2 pkp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- DGRKAMRRCD GLIDSLVHYV RGTIADYQPD DKATENCVCI LHNLSYQLEA ELPEKYSQNI YIQNRNIQTD NNKSIGCFGS RSRKVKEQYQ DVPMPEEKSN PKGVEWLWHS IVIRMYLSLI AKSVRNYTQE ASLGALQNLT AGSGPMPTSV AQTVVQKESG LQHTRKMLHV GDPSVKKTAI SLLRNLSRNL SLQNEIAKET LPDLVSIIPD TVPSTDLLIE TTASACYTLN NIIQNSYQNA RDLLNTGGIQ KIMAISAGDA. It is sometimes possible for the material contained within the vial of "Plakophilin 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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