Rabbit anti-Human PKC epsilon Polyclonal Antibody | anti-PKC epsilon antibody

PKC epsilon Antibody

Cat. Num. AAA9402280

• Gene Names: PRKCE; PKCE; nPKC-epsilon
• Reactivity: Human
• Applications: Western Blot
• Purity: Antibodies were purified by antigen-affinity chromatography.
• Synonyms: PKC epsilon; Polyclonal Antibody; PKC epsilon Antibody; MGC125656 antibody; MGC125657 antibody; PKCE antibody; nPKC-epsilon antibody; PRKCE antibody; protein kinase C epsilon type antibody; "protein kinase C; epsilon antibody"; anti-PKC epsilon antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total PKC epsilon protein.
• Purity/Purification: Antibodies were purified by antigen-affinity chromatography.
• Form/Format: Rabbit IgG in 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: 0.92 mg/ml (varies by lot)
• Sequence Length: 737

• Applicable Applications for anti-PKC epsilon antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:500-1:3000
• Immunogen Type: Recombinant Protein
• Immunogen Description: Recombinant fragment corresponding to a region within amino acids 197 and 606 of PKC epsilon.
• Target Name: PKC epsilon
• Preparation and Storage: Store at -20 degree C

Testing Data

(Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE diluted at 1:1000)

Related Product Information for anti-PKC epsilon antibody

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq]

Product Categories/Family for anti-PKC epsilon antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 4885563
• NCBI GeneID: 5581
• NCBI Accession #: NP_005391.1
• NCBI GenBank Nucleotide #: NM_005400.2
• UniProt Accession #: Q02156; Q32MQ3; Q53SL4; Q53SM5; Q9UE81; B0LPH7
• Molecular Weight: 83,674 Da
• NCBI Official Full Name: protein kinase C epsilon type
• NCBI Official Synonym Full Names: protein kinase C, epsilon
• NCBI Official Symbol: PRKCE
• NCBI Official Synonym Symbols: PKCE; nPKC-epsilon
• NCBI Protein Information: protein kinase C epsilon type
• UniProt Protein Name: Protein kinase C epsilon type
• UniProt Gene Name: PRKCE
• UniProt Synonym Gene Names: PKCE
• UniProt Entry Name: KPCE_HUMAN

NCBI Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

Uniprot Description

PKCE: an AGC kinase of the PKC family. Calcium-independent, phospholipid-dependent. Activated by inflammatory mediators and involved in nociceptive functions. PKC-epsilon null mice display decreased hypoxic pulmonary vasoconstriction.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.13; AGC group; PKC family; Eta subfamily

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: Golgi apparatus; cytoskeleton; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: actin monomer binding; calcium-independent protein kinase C activity; protein serine/threonine kinase activity; signal transducer activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; enzyme activator activity; ethanol binding; ATP binding; receptor activator activity

Biological Process: epidermal growth factor receptor signaling pathway; positive regulation of cytokinesis; platelet activation; positive regulation of I-kappaB kinase/NF-kappaB cascade; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of synaptic transmission, GABAergic; positive regulation of insulin secretion; response to morphine; positive regulation of lipid catabolic process; signal transduction; cell cycle; protein amino acid phosphorylation; peptidyl-serine phosphorylation; positive regulation of MAPKKK cascade; positive regulation of actin filament polymerization; phospholipase C activation; cell division; release of sequestered calcium ion into cytosol; macrophage activation during immune response; lipopolysaccharide-mediated signaling pathway; innate immune response; blood coagulation; cell adhesion; regulation of peptidyl-tyrosine phosphorylation