Rabbit PKC delta Polyclonal Antibody | anti-PKC delta antibody

PKC delta Rabbit Polyclonal

Cat. Num. AAA7602715

• Gene Names: PRKCD; MAY1; PKCD; ALPS3; CVID9; nPKC-delta
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PKC delta; Polyclonal Antibody; PKC delta Rabbit Polyclonal; anti-PKC delta antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 676

• Applicable Applications for anti-PKC delta antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Protein kinase C, delta
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(mouse brain tissue were subjected to SDS PAGE followed by western blot with MBS7602715 (PKC delta antibody) at dilution of 1:2000)

NCBI and Uniprot Product Information

• NCBI GI #: 938403365
• NCBI GeneID: 5580
• NCBI Accession #: NP_001303256.1
• NCBI GenBank Nucleotide #: NM_001316327.1
• Molecular Weight: 80,953 Da
• NCBI Official Full Name: protein kinase C delta type
• NCBI Official Synonym Full Names: protein kinase C delta
• NCBI Official Symbol: PRKCD
• NCBI Official Synonym Symbols: MAY1; PKCD; ALPS3; CVID9; nPKC-delta
• NCBI Protein Information: protein kinase C delta type
• UniProt Protein Name: Protein kinase C delta type
• UniProt Gene Name: PRKCD
• UniProt Synonym Gene Names: SDK1
• UniProt Entry Name: KPCD_HUMAN

NCBI Description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Uniprot Description

PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities.

Protein type: AGC group; Delta subfamily; EC 2.7.11.13; Kinase, protein; Nuclear receptor co-regulator; PKC family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; nucleoplasm; nucleus; plasma membrane

Molecular Function: calcium-independent protein kinase C activity; enzyme activator activity; enzyme binding; insulin receptor substrate binding; kinase binding; protein binding; protein kinase activity; protein kinase binding; protein kinase C activity; protein serine/threonine kinase activity

Biological Process: activation of protein kinase activity; apoptosis; cell structure disassembly during apoptosis; defense response to bacterium; histone phosphorylation; induction of apoptosis by oxidative stress; negative regulation of actin filament polymerization; negative regulation of filopodium formation; negative regulation of inflammatory response; negative regulation of insulin receptor signaling pathway; negative regulation of MAP kinase activity; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of protein binding; neutrophil activation; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phospholipase C activation; platelet activation; positive regulation of endodeoxyribonuclease activity; positive regulation of protein amino acid dephosphorylation; positive regulation of protein import into nucleus; positive regulation of superoxide release; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of mRNA stability; regulation of receptor activity; signal transduction; stimulatory C-type lectin receptor signaling pathway

Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii