Testing Data
(IPK: IP with mouse IgG (lane 1) or MBS603010 (lane 2), followed by autophosphorylation assay. )
Mouse anti-Human, Mouse JAK3 Monoclonal Antibody | anti-JAK3 antibody
JAK3 (Janus Kinase 3, EC 2.7.10.2, JAKL, Leukocyte Janus Kinase, LJAK) (MaxLight 650)
Testing Data
(IPK: IP with mouse IgG (lane 1) or MBS603010 (lane 2), followed by autophosphorylation assay. )
Testing Data
(IPK: IP with mouse IgG (lane 1) or MBS603010 (lane 2), followed by autophosphorylation assay. )
NCBI and Uniprot Product Information
Uniprot Description
JAK3: a non-receptor tyrosine-kinase of the Jak family expressed predominantly in immune cells. Mediates signal transduction via the common gamma-chain of cytokine receptors, including IL-2, -4, -7, -9, and -15. Interacts with members of the STAT (signal transduction and activators of transcription) family. Interacts with STAM2 and SHB. Contains two protein kinase domains. Mutations that abrogate JAK3 function cause an autosomal SCID (severe combined immunodeficiency disease). Inhibitor: R017s for organ transplants. Three differentially spliced isoforms have been described.
Protein type: Kinase, protein; EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; TK group; JakA family
Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; membrane; cytoplasm; intracellular; cytosol
Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; kinase activity; protein phosphatase binding; ATP binding; hormone receptor binding; protein kinase activity
Biological Process: positive regulation of immune response; peptidyl-tyrosine phosphorylation; negative regulation of T-helper 1 cell differentiation; negative regulation of FasL biosynthetic process; negative regulation of interleukin-10 production; protein amino acid autophosphorylation; positive regulation of activated T cell proliferation; protein amino acid phosphorylation; enzyme linked receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; erythrocyte differentiation; positive regulation of T cell proliferation; T cell homeostasis; inflammatory response; negative regulation of interleukin-12 production; cell migration; immune system process; cytokine and chemokine mediated signaling pathway; tyrosine phosphorylation of Stat5 protein; lymph node development; negative regulation of dendritic cell cytokine production; tyrosine phosphorylation of STAT protein; B cell differentiation; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of calcium ion transport; negative regulation of T cell activation; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on JAK3
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Product Notes
The JAK3 jak3 (Catalog #AAA6246332) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The JAK3 (Janus Kinase 3, EC 2.7.10.2, JAKL, Leukocyte Janus Kinase, LJAK) (MaxLight 650) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's JAK3 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP). Researchers should empirically determine the suitability of the JAK3 jak3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "JAK3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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