Rabbit anti-Human, Mouse PITX1 Polyclonal Antibody | anti-PITX1 antibody

PITX1 Rabbit Polyclonal

Cat. Num. AAA7602706

• Gene Names: PITX1; BFT; CCF; POTX; PTX1; LBNBG
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PITX1; Polyclonal Antibody; PITX1 Rabbit Polyclonal; anti-PITX1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 314

• Applicable Applications for anti-PITX1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
• Immunogen: Paired-like homeodomain 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human tonsillitis using MBS7602706 (PITX1 antibody) at dilution of 1:50)

Western Blot (WB)

(HeLa cells were subjected to SDS PAGE followed by western blot with MBS7602706 (PITX1 antibody) at dilution of 1:800)

NCBI and Uniprot Product Information

• NCBI GI #: 13277554
• NCBI GeneID: 5307
• Molecular Weight: 34,128 Da
• NCBI Official Full Name: PITX1 protein
• NCBI Official Synonym Full Names: paired like homeodomain 1
• NCBI Official Symbol: PITX1
• NCBI Official Synonym Symbols: BFT; CCF; POTX; PTX1; LBNBG
• NCBI Protein Information: pituitary homeobox 1
• UniProt Protein Name: Pituitary homeobox 1
• Protein Family: Pituitary homeobox
• UniProt Gene Name: PITX1
• UniProt Synonym Gene Names: BFT; PTX1
• UniProt Entry Name: PITX1_HUMAN

NCBI Description

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]

Uniprot Description

PITX1: May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Defects in PITX1 are a cause of congenital clubfoot (CCF); also known as talipes equinovarus (TEV). Clubfoot is a congenital limb deformity defined as fixation of the foot in cavus, adductus, varus, and equinus (i.e. inclined inwards, axially rotated outwards, and pointing downwards) with concomitant soft tissue abnormalities. Clubfoot may occur in isolation or as part of a syndrome. Clubfoot appears to be a multifactorial trait. Belongs to the paired homeobox family. Bicoid subfamily.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: cytoplasm; nucleolus; nucleus; transcription factor complex

Molecular Function: protein binding

Biological Process: anatomical structure morphogenesis; branchiomeric skeletal muscle development; cartilage development; embryonic hindlimb morphogenesis; myoblast cell fate commitment; negative regulation of transcription, DNA-dependent; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; transcription from RNA polymerase II promoter

Disease: Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/or Mirror-image Polydactyly; Liebenberg Syndrome