Rabbit anti-Human, mouse PICK1 Polyclonal Antibody | anti-PICK1 antibody
Rabbit anti-human PICK1 polyclonal Antibody
Western Blot (WB)
(Western blotAll lanes: PICK1 antibody at 2ug/ml+mouse brain tissueSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 47,40 kDaObserved band size: 47 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human breast cancer using MBS7005523 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human rectum tissue using MBS7005523 at dilution 1:100)
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and ACCN1 has been observed as proton-gated channels sensitive to gadolinium. Alternative splicing of this gene generates three transcript variants encoding distinct isoforms.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
PICK1: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.
Protein type: Cell development/differentiation; Ligand, receptor tyrosine kinase; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: cell junction; cytoplasm; cytoskeleton; Golgi apparatus; mitochondrion; neuron projection; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; presynaptic membrane; synapse
Molecular Function: actin filament binding; ATPase activity; enzyme binding; G-protein-coupled receptor binding; identical protein binding; metal ion binding; protein binding; protein C-terminus binding; protein domain specific binding; protein kinase C binding; receptor binding
Biological Process: cellular response to glucose starvation; DNA methylation during embryonic development; DNA methylation during gametogenesis; glial cell development; monoamine transport; neuronal ion channel clustering; positive regulation of receptor internalization; protein amino acid phosphorylation; protein kinase C activation; protein targeting; receptor clustering; retrograde vesicle-mediated transport, Golgi to ER; synaptic transmission
