Rabbit PI4K2B Polyclonal Antibody | anti-PI4K2B antibody

PI4K2B Antibody

Cat. Num. AAA9630882

• Gene Names: PI4K2B; PIK42B; PI4KIIB
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: PI4K2B; Polyclonal Antibody; PI4K2B Antibody; 2610042N09Rik; 4933409G22Rik; FLJ11105; P4K2B_HUMAN; Phosphatidylinositol 4 kinase type 2 beta; Phosphatidylinositol 4 kinase type II beta; Phosphatidylinositol 4-kinase type 2-beta; Phosphatidylinositol 4-kinase type II-beta; PI4K 2 beta; PI4K 2b; PI4K II beta; PI4K IIb; Pi4k2b; PI4KII-BETA; PI4KIIb; PIK42B; Type II phosphatidylinositol 4 kinase beta isoform; anti-PI4K2B antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: PI4K2B Antibody detects endogenous levels of PI4K2B.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-PI4K2B antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human PI4K2B.
• Conjugation: Unconjugated
• Similarity: Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.
• Tissue Specificity: Widely expressed.
• Function: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4, 5-bisphosphate (PIP2), a precursor of the second messenger inositol 1, 4, 5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking.
• Note: Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes where it is recruited by PDGF stimulation by a Rac-GTP-dependent mechanism.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-PI4K2B antibody

Cytoplasm; Membrane; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 224591401
• NCBI GeneID: 55300
• NCBI Accession #: NP_060793
• NCBI GenBank Nucleotide #: NM_018323
• UniProt Accession #: Q8TCG2; Q9NUW2
• Molecular Weight: 54,744 Da
• NCBI Official Full Name: phosphatidylinositol 4-kinase type 2-beta
• NCBI Official Synonym Full Names: phosphatidylinositol 4-kinase type 2 beta
• NCBI Official Symbol: PI4K2B
• NCBI Official Synonym Symbols: PIK42B; PI4KIIB
• NCBI Protein Information: phosphatidylinositol 4-kinase type 2-beta; PI4KII-BETA; phosphatidylinositol 4-kinase type II-beta; phosphatidylinositol 4-kinase type-II beta
• UniProt Protein Name: Phosphatidylinositol 4-kinase type 2-beta
• Protein Family: Phosphatidylinositol 4-kinase
• UniProt Gene Name: PI4K2B
• UniProt Synonym Gene Names: PI4KII-BETA
• UniProt Entry Name: P4K2B_HUMAN