Western Blot (WB)
(Western Blot analysis of PLA2G1B expression in transfected 293T cell line by PLA2G1B polyclonal antibody. Lane 1: PLA2G1B transfected lysate (16.4kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human Phospholipase A2, Secretory, Group IB Polyclonal Antibody | anti-PLA2G1B antibody
Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of PLA2G1B expression in transfected 293T cell line by PLA2G1B polyclonal antibody. Lane 1: PLA2G1B transfected lysate (16.4kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of PLA2G1B expression in transfected 293T cell line by PLA2G1B polyclonal antibody. Lane 1: PLA2G1B transfected lysate (16.4kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Uniprot Description
Function: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules. Ref.9
Catalytic activity: Phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate.
Cofactor: Binds 1 calcium ion per subunit
By similarity.
Subunit structure: Monomer or homodimer
By similarity. The inactive pro-form is a homotrimer. Ref.9
Subcellular location: Secreted. Note: secreted from pancreatic acinar cells in its inactive form. Ref.9
Post-translational modification: Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically.
Sequence similarities: Belongs to the phospholipase A2 family.
Research Articles on PLA2G1B
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Product Notes
The PLA2G1B pla2g1b (Catalog #AAA646253) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospholipase A2, Secretory, Group IB (PLA2G1B, phospholipase A2, MGC119834, MGC119835, Phosphatidylcholine 2-acylhydrolase, Phospholipase A2 precursor, PLA2, PLA2A, PPLA2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Phospholipase A2, Secretory, Group IB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the PLA2G1B pla2g1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MKLLVLAVLL TVAAADSGIS PRAVWQFRKM IKCVIPGSDP FLEYNNYGCY CGLGGSGTPV DELDKCCQTH DNCYDQAKKL DSCKFLLDNP YTHTYSYSCS GSAITCSSKN KECEAFICNC DRNAAICFSK APYNKAHKNL DTKKYCQS. It is sometimes possible for the material contained within the vial of "Phospholipase A2, Secretory, Group IB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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