Rabbit Phospholipase A2 activator protein Polyclonal Antibody | anti-PLAA antibody
Phospholipase A2 activator protein Antibody
Gene Names
PLAA; DOA1; PLAP; PLA2P
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
Phospholipase A2 activator protein; Polyclonal Antibody; Phospholipase A2 activator protein Antibody; FLJ11281; FLJ12699; Glycerophosphatase; OTTHUMP00000045176; Phospholipase A 2 activating protein; Phospholipase A-2-activating protein; Phospholipase A2 activating protein; PLA2P; Plaa; PLAP; PLAP_HUMAN; anti-PLAA antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Phospholipase A2 activator protein Antibody detects endogenous levels of total Phospholipase A2 activator protein.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-PLAA antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from Human MYOCD.
Conjugation
Unconjugated
Similarity
The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus. The PFU domain mediates interaction with ubiquitin. Belongs to the WD repeat PLAP family.
Subunit Structure
Interacts with ubiquitin. Interacts with UBXN6, VCP and YOD1; may form a complex involved in macroautophagy.
Function
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis.
Note
Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-PLAA antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
795
NCBI Official Full Name
Phospholipase A-2-activating protein
NCBI Official Synonym Full Names
phospholipase A2-activating protein
NCBI Official Symbol
PLAA
NCBI Official Synonym Symbols
DOA1; PLAP; PLA2P
NCBI Protein Information
phospholipase A-2-activating protein; DOA1 homolog; phospholipase A2 activating protein
UniProt Protein Name
Phospholipase A-2-activating protein
Protein Family
UniProt Gene Name
PLAA
UniProt Synonym Gene Names
PLAP; PLA2P; PLAP
UniProt Entry Name
PLAP_HUMAN
Uniprot Description
PLAA: phospholipase A2 activating protein. A regulator of the production of eicosanoids and prostaglandin E(2) in immune and inflammatory responses. Belongs to the WD repeat PLAP family.
Protein type: Activator
Chromosomal Location of Human Ortholog: 9p21
Molecular Function: phospholipase A2 activator activity; protein binding
Biological Process: positive regulation of catalytic activity; phospholipid metabolic process; signal transduction; inflammatory response
Research Articles on PLAA
Similar Products
Product Notes
The PLAA plaa (Catalog #AAA9629715) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospholipase A2 activator protein Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Phospholipase A2 activator protein can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the PLAA plaa for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospholipase A2 activator protein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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