Dot Blot (DB)
(Dot blot analysis of rat TSC1 Antibody (Phospho S312) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.)
Rabbit Phospho-rat TSC1 (S312) Polyclonal Antibody | anti-Tsc1 antibody
Phospho-rat TSC1 (S312) Antibody
Dot Blot (DB)
(Dot blot analysis of rat TSC1 Antibody (Phospho S312) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.)
Dot Blot (DB)
(Dot blot analysis of rat TSC1 Antibody (Phospho S312) Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.)
Di Nardo, A., et al. J. Neurosci. 29(18):5926-5937(2009)
Chen, P., et al. Exp. Mol. Pathol. 86(2):101-107(2009)
Momose, S., et al. Biochem. Biophys. Res. Commun. 356(3):693-698(2007)
Goncharova, E., et al. J. Cell Biol. 167(6):1171-1182(2004)
NCBI and Uniprot Product Information
Uniprot Description
TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.
Protein type: Tumor suppressor; Motility/polarity/chemotaxis
Cellular Component: TSC1-TSC2 complex; growth cone; cytoskeleton; protein complex; intracellular membrane-bound organelle; membrane; lamellipodium; cytoplasm; plasma membrane; actin filament; cell cortex; cytosol
Molecular Function: chaperone binding; GTPase activating protein binding; protein N-terminus binding; GTPase regulator activity
Biological Process: myelination; regulation of cell cycle; regulation of cell-matrix adhesion; protein heterooligomerization; cell-matrix adhesion; negative regulation of insulin receptor signaling pathway; negative regulation of cell size; regulation of phosphoprotein phosphatase activity; cardiac muscle cell differentiation; response to insulin stimulus; regulation of translation; negative regulation of cell proliferation; positive regulation of focal adhesion formation; cell projection organization and biogenesis; synapse organization and biogenesis; kidney development; potassium ion transport; nervous system development; negative regulation of TOR signaling pathway; protein stabilization; hippocampus development; rRNA export from nucleus; regulation of actin cytoskeleton organization and biogenesis; glucose import; regulation of stress fiber formation; negative regulation of translation; regulation of focal adhesion formation; neural tube closure; cerebral cortex development; regulation of protein kinase activity
Research Articles on Tsc1
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Product Notes
The Tsc1 tsc1 (Catalog #AAA9200715) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-rat TSC1 (S312) Antibody reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Phospho-rat TSC1 (S312) can be used in a range of immunoassay formats including, but not limited to, Dot Blot (DB), ELISA (EIA). DB~~1:500. Researchers should empirically determine the suitability of the Tsc1 tsc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Phospho-rat TSC1 (S312), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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