Rabbit Phospho-Progesterone Receptor Polyclonal Antibody | anti-Pgr antibody

Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody

Cat. Num. AAA3015164

• Reactivity: Mouse, Rat, Cow
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: Phospho-Progesterone Receptor; Polyclonal Antibody; Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody; PGR(phospho S190); NR3C3; Nuclear receptor subfamily 3 group C member 3; PGR; PR; PRA; PRB; Progesterone receptor; Progestin receptor form A; Progestin receptor form B; PRGR_RAT.; anti-Pgr antibody

• Host: Rabbit
• Reactivity: Mouse, Rat, Cow
• Clonality: Polyclonal
• Specificity: Phospho-Progesterone Receptor (Ser190) Polyclonal Antibody detects endogenous levels of Phospho-Progesterone Receptor protein only when phosphorylated at Ser190
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-Pgr antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated Synthesised phosphopeptide derived from rat Progesterone Receptor around the phosphorylation site of Ser190
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

Testing Data

Related Product Information for anti-Pgr antibody

Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. ER alpha and ER beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-Aand hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

NCBI and Uniprot Product Information

• NCBI GI #: 12408292
• NCBI GeneID: 25154
• NCBI Accession #: NP_074038.1
• NCBI GenBank Nucleotide #: NM_022847.1
• UniProt Accession #: Q63449
• Molecular Weight: 81,864 Da
• NCBI Official Full Name: progesterone receptor
• NCBI Official Synonym Full Names: progesterone receptor
• NCBI Official Symbol: Pgr
• NCBI Protein Information: progesterone receptor
• UniProt Protein Name: Progesterone receptor
• Protein Family: Protein
• UniProt Gene Name: Pgr
• UniProt Synonym Gene Names: Nr3c3; PR

NCBI Description

receptor for progesterone; regulates glutamic acid decarboxylase expression in the hypothalamus during proestrus; may mediate production of the GnRH and LH surge [RGD, Feb 2006]

Uniprot Description

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor ().