Western Blot (WB)
(Western blot analysis of extracts from JK cells, using PHLDA3 antiobdy.)
Rabbit anti-Human PHLDA3 Polyclonal Antibody | anti-PHLDA3 antibody
PHLDA3 Antibody
Immunohistochemistry: 1:50~1:100
Western Blot (WB)
(Western blot analysis of extracts from JK cells, using PHLDA3 antiobdy.)
Western Blot (WB)
(Western blot analysis of extracts from JK cells, using PHLDA3 antiobdy.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PHLDA3 antibody.)
Immunohistochemistry (IHC)
(Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using PHLDA3 antibody.)
NCBI and Uniprot Product Information
Uniprot Description
PHLDA3: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. Belongs to the PHLDA3 family. Induced by p53/TP53; expression is directly activated by p53/TP53. p53/TP53 phosphorylation on 'Ser-15' is required to activate the PHLDA3 promoter.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: cytoplasm; plasma membrane
Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-5-phosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol 3-phosphate binding
Biological Process: anatomical structure morphogenesis; negative regulation of protein kinase B signaling cascade; positive regulation of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
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Product Notes
The PHLDA3 phlda3 (Catalog #AAA9400903) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The PHLDA3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PHLDA3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100. Researchers should empirically determine the suitability of the PHLDA3 phlda3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PHLDA3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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