Goat PHLDA2 / TSSC3 Polyclonal Antibody | anti-PHLDA2 antibody

Goat Polyclonal to Human PHLDA2 / TSSC3

Cat. Num. AAA247103

• Gene Names: PHLDA2; IPL; BRW1C; BWR1C; HLDA2; TSSC3
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: PHLDA2 / TSSC3; Polyclonal Antibody; Goat Polyclonal to Human PHLDA2 / TSSC3; Anti-PHLDA2 / TSSC3 Antibody (C-Terminus) IHC-plus; PHLDA2; BWR1C; IPL; HLDA2; p17-BWR1C; BRW1C; TSSC3; Tumor-supressing STF cDNA 3; Human PHLDA2; anti-PHLDA2 antibody

• Host: Goat
• Reactivity: Gorilla, Human; Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human PHLDA2.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 152

• Applicable Applications for anti-PHLDA2 antibody: Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
• Application Notes: ELISA (1:32000), IHC-P (3.75 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic peptide C-EPSRPSPQPKPRTP from the C-terminus of human PHLDA2 (NP_003302.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Gibbon (93%); Marmoset (86%).
• Immunogen Type: Synthetic peptide
• Immunogen: PHLDA2 / TSSC3 antibody was raised against synthetic peptide C-EPSRPSPQPKPRTP from the C-terminus of human PHLDA2 (NP_003302.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Gibbon (93%); Marmoset (86%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-PHLDA2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-PHLDA2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 4507705
• NCBI GeneID: 7262
• NCBI Accession #: NP_003302.1
• NCBI GenBank Nucleotide #: NM_003311.3
• UniProt Accession #: Q53GA4; O00496
• Molecular Weight: 17,092 Da
• NCBI Official Full Name: pleckstrin homology-like domain family A member 2
• NCBI Official Synonym Full Names: pleckstrin homology-like domain, family A, member 2
• NCBI Official Symbol: PHLDA2
• NCBI Official Synonym Symbols: IPL; BRW1C; BWR1C; HLDA2; TSSC3
• NCBI Protein Information: pleckstrin homology-like domain family A member 2; p17-BWR1C; tumor-supressing STF cDNA 3; p17-Beckwith-Wiedemann region 1C; p17-Beckwith-Wiedemann region 1 C; tumor-suppressing STF cDNA 3 protein; imprinted in placenta and liver protein; tumor suppressing subtransferable candidate 3; tumor suppressing subchromosomal transferable fragment cDNA 3; beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein; tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein
• UniProt Protein Name: Pleckstrin homology-like domain family A member 2
• Protein Family: Pleckstrin homology-like domain family
• UniProt Gene Name: PHLDA2
• UniProt Synonym Gene Names: BWR1C; HLDA2; IPL; TSSC3; p17-BWR1C
• UniProt Entry Name: PHLA2_HUMAN

NCBI Description

This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010]

Uniprot Description

PHLDA2: a protein may play a role in regulating placenta growth. Contains one PH domain. Expressed in placenta and adult prostate gland. Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: membrane; cytoplasm

Biological Process: organ morphogenesis; regulation of gene expression; apoptosis; regulation of embryonic development; regulation of cell migration; placenta development