Rabbit anti-Human PHF10 Polyclonal Antibody | anti-PHF10 antibody

PHF10 Antibody, FITC conjugated

Cat. Num. AAA1494419

• Gene Names: PHF10; BAF45A; XAP135
• Reactivity: Human
• Applications: ELISA
• Purity: >95%, Protein G Purified
• Synonyms: PHF10; Polyclonal Antibody; PHF10 Antibody; FITC conjugated; PHD finger protein 10; BAF45A; BRG1-associated factor 45a; BAF45a; XAP135; anti-PHF10 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 498

• Applicable Applications for anti-PHF10 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: FITC
• Immunogen: Recombinant human PHD finger protein 10 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-107936
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-PHF10 antibody

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 194328734
• NCBI GeneID: 55274
• NCBI Accession #: NP_060758.2
• NCBI GenBank Nucleotide #: NM_018288.3
• UniProt Accession #: Q8WUB8; Q2YDA3; Q53HG8; Q9BXD2; Q9NV26
• Molecular Weight: 51,290 Da
• NCBI Official Full Name: PHD finger protein 10 isoform a
• NCBI Official Synonym Full Names: PHD finger protein 10
• NCBI Official Symbol: PHF10
• NCBI Official Synonym Symbols: BAF45A; XAP135
• NCBI Protein Information: PHD finger protein 10
• UniProt Protein Name: PHD finger protein 10
• Protein Family: PHD finger protein
• UniProt Gene Name: PHF10
• UniProt Synonym Gene Names: BAF45A; BAF45a
• UniProt Entry Name: PHF10_HUMAN

NCBI Description

This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]

Uniprot Description

PHF10: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Belongs to the SAYP family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: nucleus

Molecular Function: protein binding; zinc ion binding

Biological Process: nervous system development; regulation of transcription, DNA-dependent; transcription, DNA-dependent