Rabbit anti-Human, Mouse PGAM2 Polyclonal Antibody | anti-PGAM2 antibody

PGAM2 Rabbit Polyclonal

Cat. Num. AAA7602579

• Gene Names: PGAM2; GSD10; PGAMM; PGAM-M
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: PGAM2; Polyclonal Antibody; PGAM2 Rabbit Polyclonal; anti-PGAM2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 253

• Applicable Applications for anti-PGAM2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Phosphoglycerate mutase 2 (muscle)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human skin using MBS7602579 (PGAM2 antibody) at dilution of 1:100)

Western Blot (WB)

(mouse testis tissue were subjected to SDS PAGE followed by western blot with MBS7602579 (PGAM2 Antibody) at dilution of 1:600)

NCBI and Uniprot Product Information

• NCBI GI #: 50593010
• NCBI GeneID: 5224
• NCBI Accession #: NP_000281.2
• NCBI GenBank Nucleotide #: NM_000290.3
• Molecular Weight: 28,766 Da
• NCBI Official Full Name: phosphoglycerate mutase 2
• NCBI Official Synonym Full Names: phosphoglycerate mutase 2
• NCBI Official Symbol: PGAM2
• NCBI Official Synonym Symbols: GSD10; PGAMM; PGAM-M
• NCBI Protein Information: phosphoglycerate mutase 2
• UniProt Protein Name: Phosphoglycerate mutase 2
• Protein Family: Phosphoglycerate mutase
• UniProt Gene Name: PGAM2
• UniProt Synonym Gene Names: PGAMM; PGAM-M
• UniProt Entry Name: PGAM2_HUMAN

NCBI Description

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]

Uniprot Description

PGAM2: Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity. Defects in PGAM2 are the cause of glycogen storage disease type 10 (GSD10). A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps and excercise intolerance. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.

Protein type: EC 3.1.3.13; Phosphatase (non-protein); EC 5.4.2.4; EC 5.4.2.11; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Isomerase

Chromosomal Location of Human Ortholog: 7p13-p12

Cellular Component: cytosol; nucleus

Molecular Function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity; cofactor binding; phosphoglycerate mutase activity

Biological Process: dephosphorylation; gluconeogenesis; glycolysis; Notch signaling pathway; regulation of pentose-phosphate shunt; response to mercury ion; spermatogenesis; striated muscle contraction

Disease: Glycogen Storage Disease X