Rabbit anti-Human, Mouse Pellino 1 Polyclonal Antibody | anti-PELI1 antibody

Pellino 1 (Pellino-1, Pellino (Drosophila) Homolog 1, Peli1, D11Ertd676e, DKFZp686C18116, MGC50990, Pellino Protein, Pellino-related Intracellular-signaling Molecule, PRISM, Protein Pellino Homolog 1)

Cat. Num. AAA614422

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Serum; Whole antisera
• Synonyms: Pellino 1; Polyclonal Antibody; Pellino 1 (Pellino-1; Pellino (Drosophila) Homolog 1; Peli1; D11Ertd676e; DKFZp686C18116; MGC50990; Pellino Protein; Pellino-related Intracellular-signaling Molecule; PRISM; Protein Pellino Homolog 1); Anti -Pellino 1 (Pellino-1; anti-PELI1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Species Crossreactivity: Human, Mouse
• Purity/Purification: Serum; Whole antisera
• Form/Format: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

• Applicable Applications for anti-PELI1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of human Pellino between amino acids 100-150.
• Positive Control: Ramos or RAW
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-PELI1 antibody

Pellino 1 is the mammalian homologue of Pellino, a Drosophila Pelle-interacting protein. Pelle is a serine-threonine kinase through which Toll signaling can occur.

Product Categories/Family for anti-PELI1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 10242359
• NCBI GeneID: 57162
• UniProt Accession #: Q96FA3; Q96SM0; Q9GZY5; Q9HCX0
• Molecular Weight: 46,286 Da
• NCBI Official Full Name: pellino 1
• NCBI Official Synonym Full Names: pellino E3 ubiquitin protein ligase 1
• NCBI Official Symbol: PELI1
• NCBI Protein Information: E3 ubiquitin-protein ligase pellino homolog 1; pellino-1; protein pellino homolog 1; pellino-related intracellular-signaling molecule
• UniProt Protein Name: E3 ubiquitin-protein ligase pellino homolog 1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: PELI1
• UniProt Synonym Gene Names: PRISM; Pellino-1
• UniProt Entry Name: PELI1_HUMAN

Uniprot Description

PELI1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Found in a complex containing TRAF6, IRAK1 and IRAK4. Interacts with MAP3K7. Belongs to the pellino family.

Protein type: EC 6.3.2.19; Ligase; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: cytosol; nucleus

Molecular Function: protein binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: positive regulation of cytokine production; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of toll-like receptor 3 signaling pathway; positive regulation of toll-like receptor 4 signaling pathway; response to dsRNA; response to lipopolysaccharide; Toll signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; negative regulation of T cell proliferation; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; positive regulation of B cell proliferation; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway